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LAWRENCE SOREL COHEN, MD: A Conversation With the Editor

Published:January 21, 2008DOI:https://doi.org/10.1016/j.amjcard.2007.10.041
      Larry Cohen was born on 27 March 1933 in Brooklyn, New York, and that is where he grew up. After finishing public schools in Brooklyn in 1950, he went to Harvard College in Cambridge, Massachusetts, graduating in 1954. From there, he returned to New York City to New York University School of Medicine, where he finished in 1958. He completed his internship and his first 2 years of medical residency at Yale-New Haven Medical Center in New Haven, Connecticut. In 1962, he went to Boston, Massachusetts, as a research fellow in cardiology at the Peter Bent Brigham Hospital, completing that training in June 1964, and the next month he returned to New Haven as a senior assistant resident at the Yale-New Haven Medical Center. From 1965 to 1968, Dr. Cohen was senior investigator and head of the clinical service of the cardiology branch at the National Heart Institute in Bethesda, Maryland. After 2 years, he moved to Dallas, Texas, to be chief of clinical cardiology and associate professor of medicine at the University of Texas (Southwestern) Medical School. Two years later in 1970, he returned to New Haven as professor of medicine and chief of cardiology at Yale University School of Medicine. In 1978, he stepped down from the chief of cardiology position. In 1981, Dr. Cohen was made the Ebenezer K. Hunt Professor of Medicine at Yale University School of Medicine. He has served as acting deputy dean, deputy dean, special advisor to the dean, and the research integrity officer at Yale University School of Medicine. Through all the years, he has taught medical students, houseofficers, and cardiology fellows, plus continues to see private patients with various cardiovascular conditions. Dr. Cohen is a well-loved teacher and mentor and has received the Francis Gilman Blake Award for Outstanding Teaching of the Medical Sciences. In 1989, the Connecticut Heart Association named its auditorium in Wallingford, Connecticut, the Lawrence S. Cohen Auditorium. Larry Cohen has been President of the Association of University Cardiologists and also of the Inter-Urban Clinical Club. He was a founding member of the Yale University School of Medicine Society of Distinguished Teachers. He has been involved in numerous clinical trials during the last 20 or so years. He has been a visiting professor at 31 university medical centers in the USA and in 25 cities in non-US countries. He has been on the editorial boards at one time or another of all the major US cardiovascular journals. His investigations have led to over 125 publications in peer-reviewed medical journals, 34 chapters in various books, 9 editorials, and the editorship of 3 books. He and his lovely wife, Jane, are the proud parents of 2 very fine and successful daughters. Larry Cohen is a good friend, a great guy, and a true gentleman (Figure 1).
      Figure thumbnail gr1
      Figure 1LSC in 2007 at age of 74.
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      Selected Publications of LSC as Selected by LSC

        • Cohen L.S.
        • Freedman L.R.
        Damage to the aortic valve as a cause of death in subacute bacterial endocarditis.
        Ann Intern Med. 1961; 55: 562-564
        • Cohen L.S.
        • Fekety F.R.
        • Cluff L.E.
        Studies of the epidemiology of staphylococcal Infection: IV. The changing ecology of hospital staphylococci.
        N Engl J Med. 1962; 266: 367-372
        • Cohen L.S.
        • Fekety F.R.
        • Cluff L.E.
        Studies of the epidemiology of staphylococcal infection: V. The reporting of hospital-acquired infection.
        JAMA. 1962; 180: 805-808
        • Cohen L.S.
        • Cluff L.E.
        A study of the intestinal flora in a closed pediatric community.
        Am J Hyg. 1962; 76: 262-266
        • Cohen L.S.
        • Fekety F.R.
        • Cluff L.E.
        Treatment of a nasal carrier of staphylococcus aureus with oxacillin (5-methyl-3-phenyl-4isoxazolyl penicillin).
        Bull Johns Hopkins Hosp. 1962; 111: 315-320
        • Cohen L.S.
        • Fekety F.R.
        • Cluff L.E.
        Studies of the epidemiology of staphylococcal infection: VI. Infections in the surgical patient.
        Ann Surg. 1964; 159: 321-334
        • Cohen L.S.
        • Elliott W.C.
        • Gorlin R.
        Measurement of myocardial blood flow using krypton 85.
        Am J Physiol. 1964; 206: 997-999
        • Tafur E.
        • Cohen L.S.
        • Levine H.D.
        The normal apex cardiogram.
        Circulation. 1964; 30: 381-391
        • Tafur E.
        • Cohen L.S.
        • Levine H.D.
        The apex cardiogram in left ventricular outflow tract obstruction.
        Circulation. 1964; 10: 392-399
        • Cohen L.S.
        • Elliott W.C.
        • Rolett E.L.
        • Gorlin R.
        Hemodynamic studies during angina pectoris.
        Circulation. 1965; 31: 409-416
        • Klein M.D.
        • Cohen L.S.
        • Gorlin R.
        Krypton85 myocardial blood flow: precordial scintillation versus coronary sinus sampling.
        Am J Psychol. 1965; 209: 705-710
        • Cohen L.S.
        • Elliott W.C.
        • Klein M.D.
        • Gorlin R.
        Coronary heart disease: clinical, cinearteriographic and metabolic correlations.
        Am J Cardiol. 1966; 17: 153-168
        • Cohen L.S.
        • Mason D.
        • Braunwald E.
        The significance of an atrial gallop sound in mitral regurgitation: a clue to the diagnosis of ruptured chordae tendineae.
        Circulation. 1967; 35: 112-118
        • Cohen L.S.
        • Buccino R.A.
        • Roberts W.C.
        Acquired cor triventriculare, a rare complication of cardiomyopathy.
        Am Heart J. 1967; 73: 538-541
        • Cohen L.S.
        • Braunwald E.
        Amelioration of angina pectoris in idiopathic hypertrophic subaortic stenosis with beta-adrenergic blockade.
        Circulation. 1967; 35: 847-851
        • Morrow A.G.
        • Cohen L.S.
        • Roberts W.C.
        • Braunwald N.S.
        • Braunwald E.
        Severe mitral regurgitation following acute myocardial infarction and ruptured papillary muscle: hemodynamic findings and results of operative treatment in four patients.
        Circulation. 1968; 37 and 38: II:124-II:132
        • Strober W.
        • Cohen L.S.
        • Waldman T.A.
        • Braunwald E.
        Tricuspid regurgitation: a newly recognized cause of protein losing enteropathy, lymphocytopenia and immunologic deficiency.
        Am J Med. 1968; 44: 842
        • Cohen L.S.
        • Simon A.L.
        • Whitehouse W.C.
        • Schuette W.H.
        • Braunwald E.
        Heart motion video-tracing (radarkymography) in the diagnosis of congenital and acquired heart disease.
        Am J Cardiol. 1968; 22: 678-684
        • Cohen L.S.
        • Braunwald E.
        Chronic beta adrenergic receptor blockade in the treatment of idiopathic hypertrophic subaortic stenosis.
        Prog Cardiovasc Dis. 1968; 113: 211-221
        • O’Brien K.P.
        • Cohen L.S.
        Hemodynamic and phonocardiographic correlates of the Austin Flint murmur.
        Am Heart J. 1969; 77: 603-609
        • Cohen L.S.
        • Porterfield D.
        • Mitchell J.
        • Mullins C.
        Sequenced external pulsation in the therapy of cardiogenic shock.
        in: Hegyeli R.J. U.S. Government Printing Office, Washington, D.C.1969: 495-504 (Proceedings of Artificial Heart Program Conference, June 9–13, 1969. Washington, D.C.)
        • Cohen L.S.
        • Roberts W.C.
        Tetralogy of Fallot, its unusual variants and its simulators.
        Chest. 1970; 57: 266-274
        • Cohen L.S.
        • Mitchell J.H.
        Sequenced pulsation in the therapy of cardiogenic shock.
        Dallas Med J. 1970; 56: 208-209
        • Cohen L.S.
        • Wechsler A.S.
        • Mitchell JH Glick G.
        Depression of cardiac function by streptomycin and other antimicrobial agents.
        Am J Cardiol. 1970; 26: 505-511
        • Cohen L.S.
        • Rosenthal J.E.
        • Horner D.W.
        • Atkins J.M.
        • Matthews O.A.
        • Sarnoff S.
        Plasma levels of lidocaine after intramuscular administration.
        Am J Cardiol. 1972; 29: 520-523
        • Roberts W.C.
        • Cohen L.S.
        Left ventricular papillary muscles: description of the normal and a survey of conditions causing them to be abnormal.
        Circulation. 1972; 46: 138
        • Kisslo J.
        • Wolfson S.
        • Ross A.M.
        • Pasternak R.
        • Hammond G.L.
        • Cohen L.S.
        Ultrasound assessment of left ventricular function following aorto-coronary saphenous vein bypass grafting.
        Circulation. 1973; 48: 156-161
        • Cohen L.S.
        • Mullins C.B.
        • Mitchell J.H.
        Sequenced external counterpulsation and intraaortic balloon pumping in cardiogenic shock.
        Am J Cardiol. 1973; 32: 656-661
        • Zaret B.L.
        • Vlay S.C.
        • Freedman G.S.
        • Wolfson S.
        • Cohen L.S.
        Quantitative relationships between potassium-43 imaging and left ventricular cineangiography following myocardial infarction in man.
        Circulation. 1975; 52: 1076-1085
        • Zaret B.L.
        • DiCola V.C.
        • Donabedian R.K.
        • Puri S.
        • Wolfson S.
        • Freedman G.S.
        • Cohen L.S.
        Dual radionuclide study of myocardial uptake of potassium-43, technetium-99m stannous pyrophosphate, regional myocardial blood flow and creatine phosphokinase depletion.
        Circulation. 1976; 53: 422-428
        • Cannom D.S.
        • Levy W.
        • Cohen L.S.
        The short- and long-term prognosis of patients with transmural and nontransmural myocardial infarction.
        Am J Med. 1976; 61: 452-458
        • Pasternak R.C.
        • Cannom D.S.
        • Cohen L.S.
        Echocardiographic diagnosis of large fungal verrucca attached to the mitral valve.
        Br Heart J. 1976; 38: 1209-1212
        • Langou R.A.
        • Cohen L.S.
        The sequential external counter pulsator: a circulatory assist device.
        Yale J Biol Med. 1977; 50: 59-65
        • Zaret B.L.
        • Cohen L.S.
        Cardiovascular nuclear medicine I: evaluation of cardiac performance.
        Mod Concepts Cardiovasc Dis. 1977; 46: 33-36
        • Schrumpf J.D.
        • Sheps D.S.
        • Wolfson S.
        • Aronson A.L.
        • Cohen L.S.
        Altered hemoglobin-oxygen affinity with long-term propranolol therapy in patients with coronary artery disease.
        Am J Cardiol. 1977; 40: 76-82
        • Langou R.A.
        • Wiles J.C.
        • Cohen L.S.
        Coronary surgery for unstable angina pectoris. incidence and mortality of perioperative myocardial infarction.
        Br Heart J. 1978; 40: 767-772
        • Langou R.A.
        • Van Dyke C.
        • Tahan S.R.
        • Cohen L.S.
        Cardiovascular manifestations of tricyclic antidepressant overdose.
        Am Heart J. 1980; 100 (Oct): 458-464
        • Langou R.A.
        • Huang E.K.
        • Kelly M.J.
        • Cohen L.S.
        Predictive accuracy of coronary artery calcification and abnormal exercise test for coronary artery disease in asymptomatic men.
        Circulation. 1980; 62 (Dec): 1196-1203
        • Lesser R.L.
        • Heinemann M.H.
        • Borkowski Jr, H.
        • Cohen L.S.
        Mitral valve prolapse and amaurosis fugax.
        J Neuroophthalmol. 1981; 1: 153-160
        • Levy W.
        • Cannom D.S.
        • Cohen L.S.
        The nontransmural myocardial infarction in perspective.
        Cardiovasc Rev Rep. 1981; 2: 1285-1294
        • CASS Principal Investigators
        Myocardial infarction and mortality in the Coronary Artery Surgery Study (CASS) randomized trial.
        N Engl J Med. 1984; 310: 750-758
        • Brush J.E.
        • Cabin H.S.
        • Wohlgelernter D.
        • Hammond G.L.
        • Cohen L.S.
        Ventricular septal rupture following a clinically unrecognized myocardial infarction.
        Am Heart J. 1985; 110: 667-670
        • Kirklin J.W.
        • Adkins C.W.
        • Blackstone E.H.
        • Booth D.C.
        • Califf R.M.
        • Cohen L.S.
        • et al.
        ACC/AHA Guidelines and indications for coronary artery bypass graft surgery.
        Circulation. 1991; 83: 1125-1173
        • Cairns J.
        • Cohen L.S.
        • Colton T.
        Issues in the early termination of the aspirin component of the Physicians’ Health Study.
        Ann Epidemiol. 1991; 1: 395-405
        • Levy W.
        • Cannom D.S.
        • Cohen L.S.
        The nontransmural myocardial infarction in perspective.
        Cardiovasc Rev Rep. 1992; (Apr): 10-15
        • Marmor A.
        • Jain D.
        • Cohen L.S.
        • Nevo E.
        • Wackers F.J.T.
        • Zaret B.L.
        Left ventricular peak power during exercise: a noninvasive approach for assessment of contractile reserve.
        J Nucl Med. 1993; 34: 1877-1885
        • The TIMI IIIB Investigators
        Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction.
        Circulation. 1994; 89: 1545-1556
        • Mueller H.S.
        • Forman S.A.
        • Menegus M.A.
        • Cohen L.S.
        • Knatterud G.L.
        • Braunwald E.
        • TIMI Investigators
        Prognostic significance of nonfatal reinfarction during 3-year follow-up: results of the Thrombolysis In Myocardial Infarction (TIMI) Phase II Clinical Trial.
        J Am Coll Cardiol. 1995; 26: 900-907
        • Waxman M.
        • Cohen L.S.
        Authorship in Academia: A challenge for the Ombuds.
        J California Caucus College University Ombuds (CCCUO). 2001; 3: 15-20

      Chapters

        • Leon M.B.
        • Cohen L.S.
        Hypertrophic cardiomyopathy.
        in: Cotsonas Jr, N.J. Disease-a-Month. 28. Year Book Medical Publishers, Inc., Chicago1981: 1-86
        • Leon M.B.
        • Cohen L.S.
        Guidelines for patient management.
        in: Wenger Hellerstein Rehabilitation of the Coronary Patient. 2nd Ed. Wiley Medical, 1983: 67-95
        • Cohen L.S.
        Results of coronary bypass surgery.
        in: Annual Review Med. 38. 1987: 457-465
        • Cohen L.S.
        Management of patients after myocardial infarction.
        in: Hospital Practice. 22. 1987: 149-174
        • Cohen L.S.
        Diseases of the aorta.
        in: Cecil’s Textbook of Medicine. 18th Ed. 1988: 370-374
        • Kolansky D.M.
        • Cohen L.S.
        Immediate postoperative management.
        in: Frankl Brest Valvular Heart Disease: Comprehensive Evaluation and Treatment. 2nd Ed. F.A. Davis, Philadelphia1993: 277-291
        • Cohen L.S.
        Hypertrophic Cardiomyopathy.
        in: Rakel R.E. Conn’s Current Therapy. Elsevier Science (USA), 2003: 328-332

      Books

      1. Cohen L.S. Mock M.B. Ringqvist I. Physical Conditioning and Cardiovascular Rehabilitation. John Wiley and Sons, 1980: 324
      2. Zaret B.L. Moses M. Cohen L.S. Yale University School of Medicine Heart Book. William Morrow Publishing Co, 1992: 432 (April)
      3. Elefteriades J.A. Geha A.S. Cohen L.S. House Officer Guide to ICU Care. 2nd Ed. Raven Press, 1994: 286
        • Elefteriades J.A.
        • Cohen L.S.
        Your Heart: An Owner’s Guide.
        in: Promethius Books, 2007: 415