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Challenges of Meta-Analyses Pooling Non-Randomized Controlled Studies

      We read with interest the recent meta-analysis by Merla et al
      • Merla R.
      • Reddy N.K.
      • Wang F.
      • Uretsky B.F.
      • Barbagelata A.
      • Birnbaum Y.
      Meta-analysis of published reports on the effect of statin treatment before percutaneous coronary intervention on periprocedural myonecrosis.
      pooling data from 2 randomized trials and 7 cohort studies on the risk-benefit balance of statin pretreatment for percutaneous coronary intervention. However, we must caution that the investigators’ conclusions are undermined by several analytic drawbacks.
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