Saphenous veins grafts (SVGs) continue to be used as conduits for coronary bypass
surgery in nearly 350,000 patients annually in the United States. A possible genetic
contribution to SVG longevity has not been well studied. We analyzed 168 single nucleotide
polymorphisms from 150 candidate genes in 155 patients (2.1 SVGs/patient) followed
for 10 ± 4 years who underwent coronary angiography for clinical indications. Age
at coronary bypass was 54 ± 8 years, 61% were men, and 39% had diabetes mellitus.
At the time of study entry, 76% were on statins. SVG patency (<70% diameter stenosis,
no intervention), the primary study end point, was 60% at 5 years and 19% at 10 years.
After adjustment for other factors associated with SVG patency (male gender, p = 0.007;
low low-density lipoprotein, p = 0.016), 7 polymorphisms in 5 genes were associated
with SVG patency (p <0.01). In conclusion, these data represent an initial step toward
the use of a personalized genetic approach to coronary revascularization.
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Article info
Publication history
Accepted:
November 16,
2006
Received in revised form:
November 16,
2006
Received:
September 7,
2006
Identification
Copyright
© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
