Saphenous veins grafts (SVGs) continue to be used as conduits for coronary bypass
surgery in nearly 350,000 patients annually in the United States. A possible genetic
contribution to SVG longevity has not been well studied. We analyzed 168 single nucleotide
polymorphisms from 150 candidate genes in 155 patients (2.1 SVGs/patient) followed
for 10 ± 4 years who underwent coronary angiography for clinical indications. Age
at coronary bypass was 54 ± 8 years, 61% were men, and 39% had diabetes mellitus.
At the time of study entry, 76% were on statins. SVG patency (<70% diameter stenosis,
no intervention), the primary study end point, was 60% at 5 years and 19% at 10 years.
After adjustment for other factors associated with SVG patency (male gender, p = 0.007;
low low-density lipoprotein, p = 0.016), 7 polymorphisms in 5 genes were associated
with SVG patency (p <0.01). In conclusion, these data represent an initial step toward
the use of a personalized genetic approach to coronary revascularization.
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References
- Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events.N Engl J Med. 1986; 314: 1-6
- Heart disease and stroke statistics—2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.Circulation. 2006; 113: e85-e151
- Long-term graft patency (3 years) after coronary artery surgery: effects of aspirin: results of a VA Cooperative Study.Circulation. 1994; 89: 1138-1143
- Immediate postoperative aspirin improves vein graft patency early and late after coronary artery bypass graft surgery: a placebo-controlled, randomized study.Circulation. 1991; 83: 1526-1533
- Prognostic factors for atherosclerosis progression in saphenous vein grafts.J Am Coll Cardiol. 2000; 36: 1877-1883
- Prospective analysis after coronary-artery bypass grafting; platelet GP IIIa polymorphism (HPA-1b/PIA2) is a risk factor for bypass occlusion, myocardial infarction, and death.Thrombosis Haemost. 2000; 83: 404-407
- Coagulation factor V (Arg506→Gln) mutation and early saphenous vein graft occlusion after coronary artery bypass grafting.Thrombosis Haemost. 1998; 80: 220-224
- New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics.J Am Coll Cardiol. 2005; 46: 1965-1977
- A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts.Coron Artery Dis. 2001; 12: 493-497
- Creation of a large-scale genetic data bank for cardiovascular association studies.Am Heart J. 2005; 150: 500-506
- Identification of four gene variants associated with myocardial infarction.Am J Hum Genet. 2005; 77: 596-605
- Association of ABCA1 with late-onset Alzheimer’s disease is not observed in a case-control study.Neurosci Lett. 2004; 366: 268-271
- Controlling the false discovery rate: a practical and powerful approach to multiple testing.J R Stat Soc B. 1995; 57: 1289-1300
Centers for Disease Control and Prevention. The 29th Report from the Health, United States Series. Available at: www.ncbi.nlm.nih.gov/entrez/query.
- Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation.Endocrinology. 2006; 147: 1377-1385
- Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease.Pediatr Res. 2004; 56: 953-959
- MCIA gene polymorphism in HBDI multiplex families.Ann NY Acad Sci. 2004; 1037: 150-156
- Different HL-DR-DQ and MHC class I chain-related gene a (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population.Hum Immunol. 2004; 65: 1443-1450
- Genomic association of graft failure of the left internal thoracic artery for myocardial revascularization.J Am Coll Cardiol. 2006; 47 (165A): 4
- Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signaling pathway in endothelial cells.BMC Cell Biol. 2005; 17: 6-8
- Incorporation of vitronectin into fibrin clots.J Biol Chem. 2002; 277: 7520-7528
- Plasma vitronectin levels in patients with coronary atherosclerosis are increased and correlate with extent of disease.J Thromb Thrombolysis. 2002; 14: 221-225
Article info
Publication history
Accepted:
November 16,
2006
Received in revised form:
November 16,
2006
Received:
September 7,
2006
Identification
Copyright
© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.