Omega-3 fatty acid ethyl esters have well-known triglyceride-lowering properties and
were shown >30 years ago to inhibit platelet function. With the recent US Food and
Drug Administration (FDA) approval of these agents for treating severe triglyceride
elevations, concerns about excess bleeding naturally arise. However, an objective
assessment of the evidence for clinically significant bleeding reveals that such concerns
are unfounded. As such, the benefits of triglyceride lowering with omega-3 fatty acids
more than outweigh any theoretical risks for increased bleeding.
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References
- Safety considerations with omega-3 fatty acid therapy.Am J Cardiol. 2007; 99: 35C-43C
- Effect of dietary supplementation with n-3 fatty acids on coronary artery bypass graft patency.Am J Cardiol. 1996; 77: 31-36
- Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery.Circulation. 1990; 82: 428-438
- Effect of eicosapentaenoic acid on restenosis rate, clinical course and blood lipids in patients after percutaneous transluminal coronary angioplasty.Aust N Z J Med. 1990; 20: 549-552
- Can supplementation of diet with omega-3 polyunsaturated fatty acids reduce coronary angioplasty restenosis rate?.Eur Heart J. 1992; 13: 1626-1631
- Do fish oils prevent restenosis after coronary angioplasty?.Circulation. 1994; 90: 2248-2257
- Reduction in the rate of early restenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids.N Engl J Med. 1988; 319: 733-740
- A prospective, randomized, and double-blind trial on the effect of fish oil on the incidence of restenosis following PTCA.Cathet Cardiovasc Diagn. 1993; 28: 301-310
- Usefulness of fish oil supplements in preventing clinical evidence of restenosis after percutaneous transluminal coronary angioplasty.Am J Cardiol. 1989; 64: 294-299
- Fish oils and low-molecular-weight heparin for the reduction of restenosis after percutaneous transluminal coronary angioplasty.Circulation. 1996; 94: 1553-1560
- Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty.J Am Coll Cardiol. 1989; 13: 665-672
- Fish oil supplements for prevention of restenosis after coronary angioplasty.Int J Cardiol. 1992; 35: 87-93
- Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty.Circulation. 1992; 85: 950-956
- Randomised trial of fish oil for prevention of restenosis after coronary angioplasty.Lancet. 1989; 2: 177-181
- N-3 fatty acids do not prevent restenosis after coronary angioplasty: results from the CART [Coronary Angioplasty Restenosis Trial] study.J Am Coll Cardiol. 1999; 33: 1619-1626
- Prevention of postcoronary angioplasty restenosis by omega-3 fatty acids: main results of the Esapent for Prevention of Restenosis (ITalian Study ESPRIT).Am Heart J. 2002; 143: E5
- Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial.Lancet. 2003; 361: 477-485
- Dietary eicosapentaenoic acid and docosahexaenoic acid from fish oil: their incorporation into advanced human atherosclerotic plaques.Arterioscler Thromb. 1991; 11: 903-911
- The effect of dietary omega-3 fatty acids on coronary atherosclerosis: a randomized, double-blind, placebo-controlled trial.Ann Intern Med. 1999; 130: 554-562
- Controlled trial of fish oil for regression of human coronary atherosclerosis.J Am Coll Cardiol. 1995; 25: 1492-1498
- Dietary fatty acids in human thrombosis and hemostasis.Am J Clin Nutr. 1997; 65: 1687S-1698S
- Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration.Lancet. 1992; 339: 1003-1007
- Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients.J Am Soc Nephrol. 1992; 2: 1634-1639
- Effects of dietary fish oil on serum lipids and blood coagulation in peritoneal dialysis patients.Am J Kidney Dis. 1988; 11: 170-175
- Increased incidence of epistaxis in adolescents with familial hypercholesterolemia treated with fish oil.J Pediatr. 1990; 116: 139-141
- Fish oil treatment of hyperlipidemia in children and adolescents receiving renal replacement therapy.Pediatrics. 1991; 88: 265-268
Article Info
Publication History
Published online: November 30, 2006
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© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
