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The Need for a Systematic Review on the Safety Concerns of Nonopioid Analgesics

Published:October 06, 2006DOI:https://doi.org/10.1016/j.amjcard.2006.07.020
      We are pleased with the narrative review by Whelton
      • Whelton A.
      Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease.
      that reminds the medical community of the well-described cautions associated with the use of selective cyclooxygenase-2-selective inhibitors and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with (or at risk of) cardiovascular disease.
      • Whelton A.
      Clinical implications of nonopioid analgesia for relief of mild-to-moderate pain in patients with or at risk for cardiovascular disease.
      We are concerned, however, that the lack of a comprehensive systematic literature review as the starting point for their report may have resulted in an unbalanced presentation of the risks and benefits of NSAID and acetaminophen use in this patient population.
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