Advertisement
The American Journal of Cardiology®
Advanced SearchSave search
Coronary artery disease| Volume 97, ISSUE 9, P1274-1276, May 01, 2006

An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population

Published:March 13, 2006DOI:https://doi.org/10.1016/j.amjcard.2005.11.069
An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population
Previous ArticleComparison of Coronary Risk Factors and Quality of Life in Coronary Artery Disease Patients With Versus Without Diabetes Mellitus
Next ArticleRelation Between Obesity and Severity of Coronary Artery Disease in Patients Undergoing Coronary Angiography
      We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI). This association was assessed in 7,983 subjects of the Rotterdam Study during 14 years of follow-up. Among 345 subjects who developed a MI, the risk of mortality was 1.49 times higher in the variant carriers of the IGF-I promoter polymorphism than in the nonvariant carriers (95% confidence interval 1.10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Ren J.
        • Samson W.K.
        • Sowers J.R.
        Insulin-like growth factor I as a cardiac hormone.
        J Mol Cell Cardiol. 1999; 31: 2049-2061
        View in Article
        • Conti E.
        • Andreotti F.
        • Sciahbasi A.
        • Riccardi P.
        • Marra G.
        • Menini E.
        • Ghirlanda G.
        • Maseri A.
        Markedly reduced insulin-like growth factor-1 in the acute phase of myocardial infarction.
        J Am Coll Cardiol. 2001; 38: 26-32
        View in Article
        • Hong Y.
        • Pedersen N.L.
        • Brismar K.
        • Hall K.
        • de Faire U.
        Quantitative genetic analyses of insulin-like growth factor I (IGF-I), IGF-binding protein-1, and insulin levels in middle-aged and elderly twins.
        J Clin Endocrinol Metab. 1996; 81: 1791-1797
        View in Article
        • Vaessen N.
        • Heutink P.
        • Janssen J.A.
        • Witteman J.C.
        • Testers L.
        • Hofman A.
        • Lamberts S.W.
        • Oostra B.A.
        • Pols H.A.
        • van Duijn C.M.
        A polymorphism in the gene for IGF-I.
        Diabetes. 2001; 50: 637-642
        View in Article
        • Rietveld I.
        • Janssen J.A.
        • van Rossum E.F.
        • Houwing-Duistermaat J.J.
        • Rivadeneria F.
        • Hofman A.
        • Pols H.A.
        • van Duijn C.M.
        • Lamberts S.W.
        A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height.
        Clin Endocrinol. 2004; 61: 195-203
        View in Article
        • Bleumink G.S.
        • Rietveld I.
        • Janssen J.A.M.J.L.
        • van Rossum E.F.C.
        • Deckers J.W.
        • Hofman A.
        • Witteman J.C.M.
        • van Duijn C.M.
        • Stricker B.H.C.
        Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study).
        Am J Cardiol. 2004; 94: 384-386
        View in Article
        • Li B.
        • Setoguchi M.
        • Wang X.
        • Andreoli A.M.
        • Leri A.
        • Malhotra A.
        • Kajstura J.
        • Anversa P.
        Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart.
        Circ Res. 1999; 84: 1007-1019
        View in Article

      Article Info

      Publication History

      Published online: March 13, 2006
      Accepted: November 14, 2005
      Received in revised form: November 14, 2005
      Received: September 23, 2005

      Footnotes

      The Rotterdam Study is supported by the Erasmus Medical Center and Erasmus University, Rotterdam; Organization for Scientific Research, The Netherlands Organization for Health Research and Development, the Research Institute for Diseases in the Elderly, the Ministry of Education, Culture and Science, the Ministry of Health, Welfare and Sports, and the European Commission (DG XII), The Hague; the Municipality of Rotterdam, Rotterdam; and the Centre for Medical Systems Biology, Leiden, The Netherlands.

      Identification

      DOI: https://doi.org/10.1016/j.amjcard.2005.11.069

      Copyright

      © 2006 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2022 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX