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An Assessment of Statin Safety by Hepatologists

Published:February 06, 2006DOI:https://doi.org/10.1016/j.amjcard.2005.12.014
      The purpose of the Liver Expert Panel was to provide advice to the National Lipid Association’s (NLA) Safety Task Force in response to specific questions concerning liver-associated risks of statin therapy. The panel was composed of academic hepatologists with clinical and research interests in nonalcoholic fatty liver disease, lipid metabolic disorders, and drug hepatotoxicity.
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      References

        • Chalasani N.
        Statins and hepatotoxicity.
        Hepatology. 2005; 41: 690-695
      1. Lipitor (atorvastatin) [package insert]. Pfizer Inc, New York, NY2004
      2. Vytorin (ezetimibe-simvastatin) [package insert]. Merck/Schering-Plough Pharmaceuticals, North Wales, PA2005
      3. Zetia (ezetimibe) [package insert]. Merck/Schering-Plough Pharmaceuticals, North Wales, PA2005
        • Mofrad P.
        • Contos M.J.
        • Haque M.
        • Sargeant C.
        • Fisher R.A.
        • Luketic V.A.
        • Sterling R.K.
        • Shiffman M.L.
        • Stravitz R.T.
        • Sanyal A.J.
        Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values.
        Hepatology. 2003; 37: 1286-1292
        • Sniderman A.D.
        Is there value in liver function test and creatine phosphokinase monitoring for statin use?.
        Am J Cardiol. 2004; 94: 30F-34F
        • Vuppalanchi R.
        • Teal E.
        • Chalasani N.
        Patients with elevated baseline liver enzymes do not have higher frequency of hepatoxicity from lovastatin than those with normal baseline liver enzymes.
        Am J Med Sci. 2005; 329: 62-65
        • Chalasani N.
        • Aljadhey H.
        • Kesterson J.
        • Murray M.D.
        • Hall S.D.
        Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity.
        Gastroenterology. 2004; 126: 1287-1292
      4. Mevacor (lovastatin) [package insert]. Merck & Co. Inc, Whitehouse Station, NJ2005
      5. Zocor (simvastatin) [package insert]. Merck & Co. Inc, Whitehouse Station, NJ2004
      6. Lescol (fluvastatin) [package insert]. Novartis, East Hanover, NJ2003
      7. Pravachol (pravastatin) [package insert]. Bristol-Myers Squibb, Princeton, NJ2004
      8. Crestor (rosuvastatin) [package insert]. AstraZeneca, Wilmington, DE2005
        • de Denus S.
        • Spinler S.A.
        • Miller K.
        • Peterson A.M.
        Statins and liver toxicity.
        Pharmacotherapy. 2004; 24: 584-591
        • Russo M.W.
        • Galanko J.A.
        • Shrestha R.
        • Fried M.W.
        • Watkins P.
        Liver transplantation for acute liver failure from drug induced liver injury in the United States.
        Liver Transpl. 2004; 10: 1018-1023
        • Gotto A.M.
        Safety and statin therapy. Reconsidering the risks and benefits.
        Arch Intern Med. 2003; 163: 657-659
        • Law M.R.
        • Rudnicka A.R.
        Statin safety.
        Am J Cardiol. 2006; 97: 52C-60C
        • Pelli N.
        • Setti M.
        • Ceppa P.
        • Toncini C.
        • Indiveri F.
        Autoimmune hepatitis revealed by atorvastatin.
        Eur J Gastroenterol Hepatol. 2003; 15: 921-924
        • Siddiqui J.
        • Raina D.
        • Abraham A.
        • Alla V.
        • Chaslasani N.
        • Wu G.Y.
        • Bonkovsky H.L.
        Autoimmune hepatitis induced by statins.
        Gastroenterology. 2005; 128 ([abstract]): A171
        • Tolman K.G.
        The liver and lovastatin.
        Am J Cardiol. 2002; 89: 1374-1380
        • Smith C.C.
        • Bernstein L.I.
        • Davis R.B.
        • Rind D.M.
        • Shmerling R.H.
        Screening for statin-related toxicity.
        Arch Intern Med. 2003; 163: 688-692
        • Sandler R.S.
        • Everhart J.E.
        • Donowitz M.
        • Adams E.
        • Cronin K.
        • Goodman C.
        • Gemmen E.
        • Shah S.
        • Avdic A.
        • Rubin R.
        The burden of selected digestive diseases in the United States.
        Gastroenterology. 2002; 122: 1500-1511
        • Neuschwanter-Tetri B.A.
        • Caldwell S.H.
        Nonalcoholic steatohepatitis.
        Hepatology. 2003; 37: 1202-1219
        • Rallidis L.S.
        • Drakoulis C.K.
        • Parasi A.S.
        Pravastatin in patients with nonalcoholic steatohepatitis.
        Atherosclerosis. 2004; 174: 193-196
        • Horlander J.C.
        • Kwo P.Y.
        • Cummings O.W.
        • Koukoulis G.
        Atorvastatin for the treatment of NASH [abstract].
        Gastroenterology. 2001; 120: A544
        • Kiyici M.
        • Gulten M.
        • Gurel S.
        • et al.
        Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis.
        Can J Gastroenterol. 2003; 17: 713-718
        • Zimmerman H.J.
        Hepatotoxicity. The Adverse Effects of Drugs and Other Chemicals on the Liver. Appleton-Century-Crofts, New York1978 (181–185, 363–364)
        • Bjornsson E.
        • Olsson R.
        Outcome and prognostic markers in severe drug-induced liver disease.
        Hepatology. 2005; 42: 481-489
        • Senior J.R.
        Regulatory perspective.
        in: Kaplowitz N. DeLeve L.D. Drug Induced Liver Disease. Marcel Dekker, Inc, New York2003: 739-754