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Decreased Aortic Root Distensibility Rather Than Increased Aortic Root Diameter as an Important Cardiovascular Risk Factor in the Marfan Syndrome

Published:February 14, 2006DOI:https://doi.org/10.1016/j.amjcard.2005.12.002
      The report by Meijboom et al
      • Meijboom L.J.
      • Timmermans J.
      • Zwinderman A.H.
      • Engelfriet P.M.
      • Mulder B.J.M.
      Aortic root growth in men and women with the Marfan’s syndrome.
      on aortic root growth in men and women with the Marfan syndrome is interesting and has important clinical implications. Aortic root dilatation and related complications, such as aneurysm of the ascending aorta, aortic dissection, and aortic regurgitation, are the major causes of death in those with Marfan syndrome.
      • Murdoch J.L.
      • Walker B.A.
      • Halpern B.L.
      • Kuzma J.W.
      • McKusick V.A.
      Life expectancy and causes of death in the Marfan syndrome.
      However, it is the distensibility, rather than the diameter, of the aortic root and ascending aorta that matters in Marfan syndrome.
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