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Wrong Approach in Relating T-Wave Abnormalities to Coronary Artery Disease on Coronary Arteriography in the APPROACH Study

Published:December 15, 2005DOI:https://doi.org/10.1016/j.amjcard.2005.10.012
      I am not surprised that the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) investigators
      • Alagiakrishnan K.
      • Beitel J.D.
      • Graham M.M.
      • Southern D.
      • Knudtson M.
      • Ghali W.A.
      • Tsuyuki R.T.
      Relation of T-axis abnormalities to coronary artery disease and survival after cardiac catheterization.
      found no significant association between T-wave abnormalities on electrocardiography and the extent of coronary artery disease (CAD) on coronary arteriography. It has been known for a long time that the correlation between the extent of CAD on coronary arteriography and the presence or absence of myocardial infarct (MI) on electrocardiography is poor. Because T-wave abnormalities, just like abnormalities of the QRS complex, reflect the repolarization and depolarization processes, respectively, of the myocardium rather than its vascular supply, one can easily see why the T-wave abnormalities may not have a significant association with the extent of CAD as found in the APPROACH study.
      • Alagiakrishnan K.
      • Beitel J.D.
      • Graham M.M.
      • Southern D.
      • Knudtson M.
      • Ghali W.A.
      • Tsuyuki R.T.
      Relation of T-axis abnormalities to coronary artery disease and survival after cardiac catheterization.
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