Advertisement

Barry Lewis Zaret, MD: A conversation With the Editor

        Barry Zaret (Figure 1) was born in New York City on October 3, 1940. He grew up in Brooklyn and Queens and attended public schools before college. He graduated from Queens College in New York City, summa cum laude, in 1962 and from the New York University School of Medicine in 1966. His internship and residency in medicine was at Bellevue Hospital in New York City. His fellowship in cardiology was at The Johns Hopkins University School of Medicine from 1969 to 1971. During the next 2 years, he was a major in the US Air Force and stationed at the Travis Air Force base in California. In 1973, he moved to New Haven, Connecticut, joining the Division of Cardiology at Yale University School of Medicine, and he has been there ever since. Within 5 years, he was Chief of the Section of Cardiovascular Medicine and by 1982 he was Professor of medicine and diagnostic radiology. In 1984, he became the Robert W. Berliner Professor of medicine at Yale University School of Medicine. He is one of the founders of nuclear cardiology. He was the founding editor in chief of the Journal of Nuclear Cardiology, and he served in that capacity from 1993 to 2003. In 1999, he became medical director of the Yale New Haven Hospital Heart Center. He remained Chief of the cardiology division from 1978 to 2004 and was one of the 3 longest serving chiefs of cardiology in any university hospital in the US. Dr. Zaret has been a very productive researcher, leading to publication of nearly 200 articles in peer-reviewed medical journals plus numerous editorials, reviews, and chapters in various books. He lectures widely in the US and internationally. He has received several awards and is member of the American Society for Clinical Investigation and the Association of American Physicians. He was one of the founders and second president of the Association of Professors of Cardiology. He is also the author or editor of 5 books, one of which is now in its third edition. Barry Zaret is also a great guy. He and his wife are the proud parents of 3 sons and grandparents of 2.
        To read this article in full you will need to make a payment

        Purchase one-time access:

        Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
        One-time access price info
        • For academic or personal research use, select 'Academic and Personal'
        • For corporate R&D use, select 'Corporate R&D Professionals'

        Subscribe:

        Subscribe to American Journal of Cardiology
        Already a print subscriber? Claim online access
        Already an online subscriber? Sign in
        Institutional Access: Sign in to ScienceDirect

        Most important publications selected by BLZ

        1. Zaret BL, Strauss HW, Hurley PJ, Natarajan TP, Pitt B. A noninvasive scintiphotographic method for detecting regional ventricular dysfunction in man. N Engl J Med1971;284:1165–1170.

        2. Strauss HW, Zaret BL, Hurley PJ, Nataragan TK, Pitt B. A scintiphotographic method for measuring left ventricular ejection fraction in man without cardiac catheterization. Am J Cardiol 1971;28:575–580.

        3. Zaret BL, Strauss HW, Martin ND, Wells HP, Flamm MD Jr. Noninvasive evaluation of regional myocardial perfusion with radioactive potassium: study of patients at rest, exercise, and during angina pectoris. N Engl J Med 1973;288:809–812.

        4. Zaret BL, Stenson RE, Martin ND, Strauss HW, Well HP, McGowan RL Flamm MD Jr. Potassium-43 myocardial perfusion scanning for the noninvasive evaluation of patients with false-positive exercise tests. Circulation 1973;48:1234–1241.

        5. Martin ND, Zaret BL, Strauss HW, Wells HP, Albers J. Myocardial imaging using 43K and the gamma camera. Radiology 1974;112:446–448.

        6. Zaret BL, Martin ND, McGowan RL, Wells HP, Flamm MD Jr. Rest and exercise potassium-43 myocardial perfusion imaging for the noninvasive evaluation of aortocoronary bypass surgery. Circulation 1974;40:688–694.

        7. Zaret BL, Vlay SC, Freedman GS, Wolfson S, Cohen LS. Quantitative relationships between potassium-43 imaging and left ventricular cineangiography following myocardial infarction in man. Circulation 1975;52:1076–1085.

        8. Zaret BL, DiCola VC, Donabedian RK, Puri S, Wolfson S, Freedman GS, Cohen LS. Dual radionuclide study of myocardial infarction: relationships between myocardial uptake of potassium-43, technetium-99m stannous pyrophosphate, regional myocardial blood flow and creatine phosphokinase depletion. Circulation 1976;53:422–428.

        9. Berger HJ, Zaret BL, Speroff L, Cohen LS, Wolfson S. Cardiac prostaglandin release during myocardial ischemia in anesthetized dogs. Circ Res 1976;38:566–571.

        10. Berger HJ, Zaret BL, Speroff L, Cohen LS, Wolfson S. Cardiac prostaglandin release during myocardial ischemia induced by pacing in patients with coronary artery disease. Am J Cardiol 1977;39:481–486.

        11. DiCola VC, Freedman GS, Downing SE, Zaret BL. Myocardial uptake of technetium-99 stannous pyrophosphate following direct current countershock. Circulation 1976;54:980–986.

        12. DiCola VC, Downing SE, Donabedian RK, Zaret BL. Pathophysiologic correlates of thallium-01 myocardial uptake in experimental infarction. Cardiovasc Res 1977;11:141–146.

        13. Marshall RC, Berger HJ, Costin JC, Freedman GS, Wolberg J, Cohen LS, Gottschalk A, Zaret BL. Assessment of cardiac performance with quantitative radionuclide angiocardiography: sequential left ventricular ejection fraction: normalized left ventricular ejection rate, and regional wall motion. Circulation 1977;56:820–829.

        14. Caride VJ, Zaret BL. Liposome accumulation in regions of experimental myocardial infarction. Science 1977;198:735–738.

        15. Berger HJ, Matthay RA, Loke J, Marshall RC, Gottschalk A, Zaret BL. Assessment of cardiac performance with quantitative radionuclide angiocardiography: right ventricular ejection fraction with reference to findings in chronic obstructive pulmonary disease. Am J Cardiol1978;41:897–905.

        16. Berger HJ, Gottschalk A, Zaret BL. Dual radionuclide study of myocardial infarction: comparison of thallium-201 and technetiaum-99m stannous pyrophosphate imaging in man. Ann Intern Med 1978;88:145–154.

        17. Marshall RC, Berger HJ, Reduto LA, Gottschalk A, Zaret BL. Variability in sequential measures of left ventricular performance assessed by radionuclide angiocardiography. Am J Cardiol 1978;41:531–536.

        18. Marshall RC, Berger HJ, Reduto LA, Cohen LS, Gottschalk A, Zaret BL. Assessment of cardiac performance with quantitative radionuclide angiocardiography: effects of oral propranolol on global and regional left ventricular function in coronary artery disease. Circulation 1978;58:808–814.

        19. Riba A, Downs J, Thakur ML, Gottschalk A, Andriole VT, Zaret BL. Technetium-99 stannous pyrophosphate imaging of infective endocarditis. Circulation 1978;58:111–119.

        20. Matthay RA, Berger HJ, Loke J, Gottschalk A, Zaret BL. Effects of aminophylline on right and left ventricular performance in chronic obstructive pulmonary diseases: noninvasive assessment by radionuclide angiocardiography. Am J Med 1978;65:903–910.

        21. Reduto LA, Berger HJ, Cohen LS, Gottschalk A, Zaret BL. Sequential radionuclide assessment of left and right ventricular performance following acute transmural myocardial infarction. Ann Intern Med 1978;89:441–447.

        22. Berger HJ, Reduto LA, Johnstone DE, Borowski H, Sands JM, Cohen LS, Langou RA, Gottschalk A, Zaret BL. Global and regional left ventricular response to bicycle exercise in coronary artery disease: assessment by quantitative radionuclide angiocardiography. Am J Med 1979;66:13–221.

        23. Alexander J, Dainiak N, Berger HJ, Goldman L, Johnstone D, Reduto L, Duffy T, Schwartz P, Gottschalk A, Zaret BL. Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography. N Engl J Med 1979;300:278–283.

        24. Wackers FJ, Berger HJ, Johnstone DE, Goldman L, Reduto LA, Langou RA, Gottschalk A, Zaret BL. Multiple gated cardiac blood pool imaging for left ventricular ejection fraction: validation of the technique and assessment of variability. Am J Cardiol 1979;43:1159–1166.

        25. Thakus ML, Gottschalk A, Zaret BL. Imaging experimental myocardial infarction with indium-111 labeled autologous leukocytes: effects of infarct age and residual regional myocardial blood flow. Circulation 1979;60:297–305.

        26. Berger HJ, Johnsone DD, Sands MJ, Gottschalk A, Zaret BL. Response of right ventricular ejection fraction to upright bicycle exercise in coronary artery disease. Circulation 1979;60:1292–1299.

        27. Riba AL, Thakur ML, Gottschalk A, Zaret BL. Imaging experimental coronary artery thrombosis with indium-III platelets. Circulation 1979;60:767–775.

        28. Goldman L, Feinstein AR, Batsford WP, Cohen LS, Gottschalk A, Zaret BL. Ordering patterns and clinical impact of cardiovascular nuclear medicine procedures. Circulation 1980;62:680–687.

        29. Reduto LA, Berger HJ, Johnstone DE, Hellenbrand W, Wackers FJ, Wittemore R, Cohen LS, Gottschalk A, Zaret BL. Radionuclide assessment of right and left ventricular exercise reserve following total correction of tetralogy of Fallot. Am J Cardiol 1980;45:1013–1018.

        30. Matthay RA, Berger HJ, Davies RA, Loke J, Mahler DA, Gottschalk A, Zaret BL. Radionuclide assessment of right and left ventricular exercise performance in chronic obstructive pulmonary disease. Ann Intern Med 1980;93:234–239.

        31. Davies RA, Thakur ML, Berger HJ, Wackers FJ, Gottschalk A, Zaret BL. Imaging the inflammatory response to acute myocardial infarction in man using indium-111 labeled autologous leukocytes. Circulation 1981;63:826–832.

        32. Hoffer P, Berger H, Steidley J, Brendel A, Gottschalk A, Zaret BL. Miniaturized cadmium telluride detector module for continuous monitoring of left ventricular performance. Radiology 1981;138:477–481.

        33. Berger HJ, Sands MJ, Davies RA, Wackers FJ, Alexander J, Lachman AB, Williams BW, Gottschalk A, Zaret BL. Exercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries. Ann Intern Med 1981;94:186–191.

        34. Rutlen DL, Wackers FJ, Zaret BL. Radionuclide assessment of peripheral intravascular capacity: a new technique to measure intravascular volume changes in the capacitance circulation in man. Circulation 1981;64:146–152.

        35. Berger HJ, Daview RA, Batsford WP, Hoffer PB, Gottschalk A, Zaret BL. Beat-to-beat left ventricular performance assessed from the equilibrium cardiac blood pool using a computerized nuclear probe. Circulation 1981;63:133–142.

        36. Wackers RJ, Klay JW, Laks H, Schnitzer J, Zaret BL, Geha AS. Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model. Circulation 1981;64:1256–1264.

        37. Lewis SM, Riba AL, Berger HJ, Davies RA, Wackers FJ, Alexander J, Sands MJ, Cohen LS, Zaret BL. Radionuclide angiographic exercise left ventricular performance in chronic aortic regurgitation: relationships to resting echographic ventricular dimensions and systolic wall stress index. Am Heart J 1982;133:498–504.

        38. Wackers FJ, Berger HJ, Weinberg MA, Zaret BL. Spontaneous changes in left ventricular function over the first 24 hours of acute myocardial infarction: implication for evaluating early therapeutic interventions. Circulation 1982;66:748–754.

        39. Wackers FJ, Giles RW, Hoffer PB, Lange RC, Berger HJ, Zaret BL. Gold 195-m, a new generator produced short-lived radionuclide for sequential assessment of ventricular performance by first-pass radionuclide angiocardiography. Am J Cardiol 1982;50:89–94.

        40. Giles RW, Berger HJ, Barash PG, Tarabadkar S, Marx PG, Hammond GL, Geha AS, Laks H, Zaret BL. Profound alterations in left ventricular performance during anesthesia induction for coronary artery bypass surgery. Am J Cardiol 1982;50:735–741.

        41. Schneider J, Berger HJ, Sands MJ, Lachman AB, Zaret BL. Beat-to-beat left ventricular performance in atrial fibrillation: radionuclide assessment with the computerized nuclear probe. Am J Cardiol 1983;51:1189–1195.

        42. Choi BW, Berger HJ, Schwartz PE, Alexander J, Wackers FJ, Gottschalk A, Zaret BL. Serial radionuclide assessment of doxorubicin cardiotoxicity in cancer patients with abnormal baseline resting left ventricular performance. Am Heart J 1983;106:638–642.

        43. Brent BN, Berger HJ, Matthay RA, Mahler D, Pytlik L, Zaret BL. Contrasting acute effects of vasodilators upon right ventricular performance in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Am J Cardiol 1983;51:1682–1689.

        44. Wackers FJ, Stein R, Pytlik L, Plankey MW, Lang R, Hoffer PB, Sand MJ, Zaret BL, Berger HJ. Gold-195m for serial first pass radionuclide angiocardiography during upright exercise in patients with coronary artery disease. J Am Coll Cardiol 1983;2:497–505.

        45. Brent BN, Mahler D, Matthay RA, Berger HJ, Zaret BL. Noninvasive diagnosis of pulmonary hypertension in chronic obstructive pulmonary disease: utility of resting right ventricular ejection fraction. Am J Cardiol 1984;53:1349–1353.

        46. Barrett EJ, Schwartz RG, Francis CK, Zaret BL. Regulation of insulin of myocardial glucose and fatty acid metabolism in the conscious dog. J Clin Invest 1984;74:1073–1079.

        47. Meizlish JL, Berger HJ, Plankey M, Errico D, Levy W, Zaret BL. Functional left ventricular aneurysm formation following acute anterior transmural myocardial infarction: incidence, natural history and prognostic implications. N Engl J Med 1984;311:1001–1006.

        48. Soufer R, Wohlgelertner D, Vita NA, Amuchestegui M, Sostman DH, Berger HJ, Zaret BL. Intact systolic left ventricular function in clinical congestive heart failure. Am J Cardiol 1985;55:1032–1036.

        49. Mahler DA, Matthay RA, Snyder PE, Pytlik L, Zaret BL, Loke J. Volumetric responses of the right and left ventricles during upright exercise in normal subjects. J Appl Physiol 1985;58:1818–1822.

        50. Schwartz RG, Barrett EJ, Francis CK, Jacobv R, Zaret BL. Regulation of myocardial amino acid metabolism in the conscious dog. J Clin Invest 1985;75:1204–1211.

        51. Ezekowitz M, Pope CF, Sostman HD, Smith EO, Glockman M, Rapaport S, Sniderman KW, Friedlaender G, Pelker RR, Taylor FB, Zaret BL. Indium-111 platelet scintigraphy for the diagnosis of acute venous thrombosis. Circulation 1986;73:668–674.

        52. Wohlgelernter D, Cleman M, Highman HA, Fetterman BS, Duncan JS, Zaret BL, Jaffe CC. Regional myocardial dysfunction during coronary angioplasty. J Am Coll Cardiol 1986;7:1245–1254.

        53. Schwartz RG, McKenzie WB, Alexander J, Sager P, D'Souza A, Schwartz PE, Berger HJ, Wackers FJ, Surkin L, Setaro J, Zaret BL. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy: a seven year experience using serial radionuclide angiocardiography. Am J Med 1987;82:1109–1118.

        54. Young LH, Zaret BL, Barrett EJ. Myocardial amino acid transported by canine sarcolemma vesicles. Am J Physiol 1987;21:1070–1076.

        55. Cabin HS, Clubb KS, Vita N, Zaret BL. Regional dysfunction by equilibrium radionuclide angiocardiography: a clinicopathologic study evaluating the relation of degree of dysfunction to the presence and extent of myocardial infarction. J Am Coll Cardiol 1987;10:743–747.

        56. Sheehan FH, Braunwald E, Canner PL, Dodge HT, Gore J, Ban Natta P, Passamani ER, Williams DO, Zaret BL. The effect of intravenous thrombolytic therapy of left ventricular function: a report of tissue plasminogen activator and streptokinase from the Thrombolysis In Myocardial Infarction (TIMI Phase I) trial. Circulation 1987;75:817–829.

        57. Schulman DS, Biondi JW, Matthay RA, Barash PG, Zaret BL, Soufer R. Effect of positive end-expiratory pressure on right ventricular performance: importance of baseline right ventricular function. Am J Med 1987;84:57–67.

        58. Barrett EJ, Schwartz RG, Young LH, Jacob R, Zaret BL. The effect of chronic diabetes on myocardial fuel metabolism and insulin sensitivity. Diabetes 1988;37:943–948.

        59. Bowman LK, Lee FA, Jaffe CC, Mattera J, Wackers FJ, Zaret BL. Peak filling rate normalized to stroke volume: a new Doppler echocardiographic filling index validated by radionuclide angiographic techniques. J Am Coll Cardiol 1988;12:937–943.

        60. Schulman DS, Biondi JW, Matthay RS, Zaret BL, Soufer R. Differing responses in ventricular filling, loading and volumes during positive end-expiratory pressure in man. Am J Cardiol 1989;64:772–777.

        61. Wackers FJ, Terrin ML, Kayden DS, Knatterud G, Forman S, Braunwald E, Zaret BL. Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: results of Phase I Thrombolysis In Myocardial Infarction (TIMI II) Phase II pilot study. Am J Cardiol 1989;634:503–512.

        62. Setaro JF, Zaret BL, Schulman DS, Black HR, Soufer R. Usefulness of verapamil for congestive heart failure associated with abnormal diastolic filling and normal left ventricular systolic performance. Am J Cardiol 1990;66:981–986.

        63. Bell L, Hennecken JR, Zaret BL, Rutlen DL. Alpha adrenergic regulation of splanchnic volume and cardiac output in the dog. Acta Physiol Scand 1990;138:321–329.

        64. Kayden DS, Wackers FJ, Zaret BL. Silent left ventricular dysfunction during routine activity following thrombolytic therapy for acute myocardial infarction: a predictor of subsequent cardiac morbidity. J Am Cardiol 1990;15:1500–1507.

        65. Setaro JF, Zaret BL, Schulman DS, Black HR, Soufer R. Usefulness of verapamil for congestive heart failure associated with abnormal diastolic filling and normal left ventricular systolic performance. Am J Cardiol 1990;66:981–986.

        66. Young LH, McNulty PH, Morgan C, Deckelbaum LI, Zaret BL, Barrett EJ. Myocardial protein turnover in patients with coronary artery disease: effect of branched chain amino acid infusion. J Clin Invest 1991;87:554–560.

        67. Kayden DS, Remetz MS, Cabin HS, Deckelbaum LI, Cleman MW, Wackers FJ, Zaret BL. Validation of continuous radionuclide left ventricular function monitoring in detecting silent myocardial ischemia during balloon angioplasty of the left anterior descending coronary angioplasty. Am J Cardiol 1991;67:1339–1343.

        68. Zaret BL, Wackers FJ, Terrin ML, Ross R, Weiss M, Slater J, Morrison JR, Bourge RC, Passamani E, Knatterud G, Braunwald E. Assessment of global and regional left ventricular performance at rest and during exercise following thrombolytic therapy for acute myocardial infarction: results of the Thrombolysis In Myocardial Infarction (TIMI) II study. Am J Cardiol 1992;69:1–9.

        69. Setaro JF, Soufer R, Remetz MS, Perlmutter RA, Zaret BL. Long-term outcome in patients with congestive heart failure and intact systolic left ventricular performance. Am J Cardiol 1992;69:1212–1216.

        70. Burg MM, Jain D, Soufer R, Kerns RD, Zaret BL. Role of behavioral and psychological factors in mental-stress induced silent left ventricular dysfunction in coronary artery disease. J Am Coll Cardiol 1993;22:440–448.

        71. Marmor A, Jain D, Cohen LS, Nevo E, Wackers FJ, Zaret BL. Left ventricular peak power during exercise: a noninvasive approach for assessment of contractile reserve. J Nucl Med 1993;34:1877–1885.

        72. Sinusas AJ, Shi QX, Vitols PJ, Fetterman RC, Maniawski P, Zaret BL, Wackers FJ. Impact of regional ventricular function, geometry and dobutamine stress on quantitative 99m-Tc-sestamibi defect size. Circulation 1993;88:2224–2234.

        73. Elefteriades JA, Tolis G Jr, Levi E, Mills KL, Zaret BL. Coronary artery bypass grafting in severe left ventricular dysfunction: excellent survival with improved ejection fraction and functional state. J Am Coll Cardiol 1993;22:1411–1417.

        74. Jain D, Wackers FJ, Mattera J, McMahon M, Sinusas AJ, Zaret BL. Biokinetics of 99m Tc-tetrofosmin, myocardial perfusion imaging agent: implications for a one day imaging protocol. J Nucl Med 1993;34:1254–1259.

        75. Haronian HL, Remetz MS, Sinusas AJ, Baron JM, Miller HI, Cleman MW, Zaret BL, Wackers FJ. Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: comparison to coronary angiography. J Am Coll Cardiol 1993;22:1033–1043.

        76. Sinusas AJ, Shi QX, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. J Nucl Med 1994;35:664–671.

        77. Haronian HL, Sinusas AJ, Remetz MS, Brennan JJ, Cabin HS, Zaret BL, Wackers FJ. Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: perfusion imaging during coronary angioplasty. J Nucl Cardiol 1994;1:150–158.

        78. Raiker K, Sinusas AJ, Wackers FJ, Zaret BL. One year prognosis of patients with normal planar or SPECT Tc-99m sestamibi exercise imaging. J Nucl Cardiol 1994;1:449–456.

        79. Soufer R, Dey HM, Ng CK, Zaret BL. Comparison of sestamibi single-photon emission computed tomography with positron emission tomography for estimating left ventricular viability. Am J Cardiol 1995;75:1214–1219.

        80. Jain D, Burg M, Soufer R, Zaret BL. Prognostic implications of mental stress induced silent left ventricular dysfunction in patients with stable angina pectoris. Am J Cardiol 1995;76:31–35.

        81. Zaret BL, Wackers FJ, Terrin ML, Forman SA, Williams DO, Knatterud GL, Braunwald E. Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: results of Thrombolysis In Myocardial Infarction (TIMI) Phase II study. J Am Coll Cardiol 1995;26:73–79.

        82. Zaret BL, Rigo P, Wackers FJ, Hendel RC, Braat SH, Iskandrian AS, Sridhara BS, Jain D, Itti R, Serafini AN, Goris ML, Lahiri A, and the Tetrofosmin International Trial Study Group. Myocardial perfusion imaging with 99m-Tc tetrofosmin: comparison to 201-TL imaging and coronary angiography in a phase III multicenter trial. Circulation 1995;91:313–319.

        83. McNulty PH, Louard RJ, Deckelbaum LI, Zaret BL, Young LH. Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance. Circulation 1995;92:2151–2156.

        84. Fleisher LA, Rosenbaum SG, Nelson AH, Jain D, Wackers FJ, Zaret BL. Preoperative dypridamole thallium imaging and ambulatory electrocardiographic monitoring as a predictor of perioperative cardiac events and long-term outcome. Anesthesiology 1995;83:897–901.

        85. Jain D, Thompson B, Wackers FJ, Zaret BL. Relevance of increased lung thallium uptake on stress imaging in patients with unstable angina and non-Q wave myocardial infarction: results of the Thrombolysis In Myocardial Infarction (TIMI)-IIIB study. J Am Coll Cardiol 1997;30:421–429.

        86. Gradel C, Jain D, Batsford WP, Wackers FJ, Zaret BL. Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease. J Nucl Cardiol 1997;4:379–386.

        87. Jain D, Shaker SM, Burg M, Wackers FJ, Soufer R, Zaret BL. Effects of mental stress on left ventricular and peripheral vascular performance in patients with coronary artery disease. J Am Coll Cardiol 1998;31:1314–1322.

        88. Soufer R, Bremmer JD, Arrighi JA, Cohen I, Zaret BL, Burg MM, Goldman-Rakic P. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proc Natl Acad Sci 1998;95:6454–6459.

        89. Liu YH, Sinsas AJ, DeMan PB, Natale D, Zaret BL, Wackers FJ. Quantification of SPECT myocardial perfusion images: methodology and validation of the Yale-CQ method. J Nucl Cardiol 1999;6:190–204.

        90. Arrighi JA, Burg M, Cohen IS, Kao AH, Pfau S, Caulin-Glaser T, Zaret BL, Soufer R. Quantitative myocardial blood flow response to mental stress in patients with chronic coronary artery disease: correlation with coronary angiography and comparison with flow responses in normals. Lancet 2000;356:310–311.

        91. Jain D, Joska T, Lee FA, Burg M, Lampert R, Zaret BL. Day-to-day reproducibility of mental stress-induced left ventricular dysfunction in patients with coronary artery disease and its relationship to autonomic activation. J Nucl Cardiol 2001;65:597–605.

        92. Mitani I, Jain D, Joska TM, Burtness B, Zaret BL. Doxorubicin cardiotoxicity: prevention of congestive heart failure with serial cardiac function monitoring with equilibrium radionuclide angiocardiography in the current era. J Nucl Cardiol 2003;10:132–139.

        93. Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Luo G, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR. Detection of injury-induced vascular remodeling by targeting activated αγβ3 integrin in vivo. Circulation 2004;110:84–90.

        94. Meoli DF, Sadeghi MM, Krassilnikova S, Bourke B, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri J, Zaret BL, Sinusas AJ. Non-invasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest 2004;113:1684–1691.