Advertisement

Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening

      Increased thickness and stiffness of large arteries may contribute to why aging is the most important risk for cardiovascular diseases. Arterial stiffness, intimal medial thickness, and alcohol intake were measured in 563 subjects. A U-shaped relation was found between alcohol intake and a stiffness index, with the lowest index in moderate drinkers, which may partially explain the relation between alcohol and cardiovascular disease.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. Shock NW, Greulich RC, Andres RA, Arenberg D, Costa PT Jr, Lakatta EG, Tobin JD. Normal Human Aging: The Baltimore Longitudinal Study of Aging: NIH publication 84–2450; 1984.

        • Nagai Y.
        • Metter E.J.
        • Earley C.J.
        • Kemper M.K.
        • Becker L.C.
        • Lakatta E.G.
        • Fleg J.L.
        Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia.
        Circulation. 1998; 98: 1504-1509
        • Nagai Y.
        • Earley C.J.
        • Kemper M.K.
        • Bacal C.S.
        • Metter E.J.
        Influence of age and postmenopausal estrogen replacement therapy on carotid arterial stiffness in women.
        Cardiovasc Res. 1999; 4: 307-311
        • Kawasaki T.
        • Sasayama S.
        • Yagi S.
        • Asakawa T.
        • Hirai T.
        Non-invasive assessment of the age related changes in stiffness of major branches of the human arteries.
        Cardiovasc Res. 1987; 21: 678-687
        • Bland J.M.
        • Altman D.G.
        Statistical methods for assessing agreement between two methods of clinical measurements.
        Lancet. 1986; 1: 307-310
        • Talbot L.A.
        • Metter E.J.
        • Fleg J.L.
        Leisure-time physical activities and their relationship to cardiorespiratory fitness in healthy men and women 18–95 years old.
        Med Sci Sports Exerc. 2000; 32: 417-425
        • Lakatta E.G.
        • Levy D.
        Arterial and cardiac aging: major shareholders in cardiovascular disease enterprise. Part I: Aging arteries: a “set-up” for vascular disease.
        Circulation. 2003; 107: 139-146
        • Liao D.
        • Arnett D.K.
        • Tyroler H.A.
        • Riley W.A.
        • Chambless L.E.
        • Szklo M.
        • Heiss G.
        Arterial stiffness and the development of hypertension.
        Hypertension. 1999; 34: 201-206
        • O'Leary D.H.
        • Polak J.F.
        • Kronmal R.A.
        • Manolio T.A.
        • Burke G.L.
        • Wolfson Jr, S.K.
        Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults.
        N Engl J Med. 1999; 340: 14-22
        • Boutouyrie P.
        • Tropeano A.I.
        • Asmar R.
        • Gautier I.
        • Benetos A.
        • Lacolley P.
        • Laurent S.
        Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study.
        Hypertension. 2002; 39: 10-15
        • Bots M.L.
        • Dijk J.M.
        • Oren A.
        • Grobbee D.E.
        Carotid intima-media thickness, arterial stiffness and risk of cardiovascular disease: current evidence.
        J Hypertens. 2002; 20: 2317-2325
        • Marmot M.
        • Brunner E.
        Alcohol and cardiovascular disease: the status of the U shaped curve.
        BMJ. 1991; 303: 565-568
        • Sacco R.L.
        • Elkind M.
        • Boden-Albala B.
        • Lin I.F.
        • Kargman D.E.
        • Hauser W.A.
        • Shea S.
        • Paik M.C.
        The protective effect of moderate alcohol consumption on ischemic stroke.
        JAMA. 1999; 281: 53-60
        • Rimm E.B.
        • Williams P.
        • Fosher K.
        • Criqui M.
        • Stampfer M.J.
        Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors.
        BMJ. 1999; 319: 1523-1528
        • Sehested J.
        • Heringlake M.
        • Schmidt V.
        Neurohumoral cardiovascular responses to alcohol and their modulation by peroral fluid.
        Am J Cardiol. 1998; 81: 761-765
        • Fazio M.
        • Bardelli M.
        • Macaluso L.
        • Fiammengo F.
        • Mattei P.L.
        • Bossi M.
        • Fabris B.
        • Fischetti F.
        • Pascazio L.
        • Candido R.
        • Carretta R.
        Mechanics of the carotid artery wall and baroflex sensitivity after acute ethanol administration in young healthy volunteers.
        Clin Sci (Lond). 2001; 101: 253-260
        • Mahmud A.
        • Feely J.
        Divergent effect of acute and chronic alcohol on arterial stiffness.
        Am J Hypertens. 2002; 15: 240-243
        • Sierksma A.
        • Muller M.
        • van der Schouw Y.T.
        • Grobbee D.E.
        • Hendriks H.F.J.
        • Bots M.L.
        Alcohol consumption and arterial stiffness in men.
        J Hypertens. 2004; 22: 357-362
        • Sierksma A.
        • Lebrun C.E.I.
        • van der Schouw Y.T.
        • Grobbee D.E.
        • Lamberts S.W.J.
        • Hendriks H.F.J.
        • Bots M.L.
        Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal women.
        Arterioscler Thromb Vasc Biol. 2004; 24: 342-348
        • Demirovic J.
        • Nabulsi A.
        • Folsom A.R.
        • Carpenter M.A.
        • Szklo M.
        • Sorlie P.D.
        • Barnes R.W.
        Alcohol consumption and ultrasonographically assessed carotid artery wall thickness and distensibility.
        Circulation. 1993; 88: 2787-2793