Circulating B-type natriuretic peptide (BNP) is a strong predictor of survival in
patients with acute coronary syndromes and in patients with congestive heart failure.
Whether circulating BNP levels are predictive of long-term survival in patients with
angiographically documented, clinically stable coronary artery disease is unknown.
We studied 186 patients with stable angina pectoris and angiographic evidence of significant
coronary artery disease. Patients with a recent myocardial infarction, electrocardiographic
evidence of ongoing ischemia, anginal pain at rest, or symptomatic congestive heart
failure were excluded from the study. During a follow-up of 7.4 years, 23 patients
died. By Cox proportional-hazards regression, patient age (p = 0.031), pathologic
Q waves on the electrocardiogram (p = 0.037), left ventricular ejection fraction (p
= 0.016), and plasma BNP (p = 0.008) were significantly associated with long-term
survival. In a stepwise forward multivariate model, BNP (p = 0.005) provided prognostic
information above and beyond conventional risk markers. In patients with clinically
stable, angiographically documented coronary artery disease, plasma BNP levels are
independently related to long-term survival.
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Article info
Publication history
Accepted:
August 19,
2004
Received:
July 28,
2004
Footnotes
This study was supported by grants from the research funds of the Central Hospital in Rogaland, Rogaland, Norway, and the University of Bergen, Bergen, Norway.
Identification
Copyright
© 2005 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
