Advertisement

Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction

      This study evaluated left ventricular diastolic function with Doppler echocardiography before and after statin therapy. Statin therapy worsened diastolic parameters in most patients; coenzyme Q10 supplementation in patients with worsening diastolic function with statin therapy improved parameters of diastolic function.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Langsjoen P.H.
        • Langsjoen A.M.
        The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10.
        BioFactors. 2003; 18: 101-111
        • Rundek T.
        • Naini A.
        • Sacco R.
        • Coates K.
        • DiMauro S.
        Atorvastatin decreases the conenzyme Q 10 level in the blood of patients at risk for cardiovascular disease and stroke.
        Arch Neurol. 2004; 61: 889-892
        • Krum H.
        • McMurray J.J.
        Statins and chronic heart failure: do we need a large-scale outcome trial?.
        J Am Coll Cardiol. 2002; 39: 1567-1573
        • Ghirlanda G.
        • Oradei A.
        • Manto A.
        • Lippa S.
        • Uccioli L.
        • Caputo S.
        • Greco A.V.
        • Littarru G.P.
        Evidence of plasma CoQ10 lowering effect by HMG-CoA reductase inhibitors: double blind placebo controlled study.
        J Clin Pharmacol. 1993; 33: 226-229
        • Mortensen S.A.
        • Leth A.
        • Agner E.
        • Rohde M.
        Dose related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.
        Mol Aspects Med. 1997; 18: S137-S144
        • Bargossi A.M.
        • Battino M.
        • Gaddi A.
        • Fiorella P.L.
        • Grossi G.
        • Barozzi G.
        • Di Giulio R.
        • Descovich G.
        • Sassi S.
        • Genova M.L.
        Exogenous CoQ10 preserves plasma ubiqinone levels inpatients treated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
        Int J Clin Lab Res. 1994; 24: 171-176
        • Sever P.S.
        • Dahlof B.
        • Poulter N.R.
        • Wedel H.
        • Beevers G.
        • Caulfield M.
        • Collins R.
        • Kjeldsen S.E.
        • Kristinsson A.
        • McInnes G.T
        • et al.
        • ASCOT Investigators
        Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial.
        Lancet. 2003; 361: 1149-1158
        • Athyros V.G.
        • Papageorgiou A.A.
        • Mercouris B.R.
        • Athyrou V.V.
        • Symeonidis A.N.
        • Basayannis E.O.
        • Demitriadis D.S.
        • Kontopoulos A.G.
        Treatment with atorvastatin to the National Cholesterol Educational Program goal versus “usual” care in secondary coronary heart disease prevention.
        Curr Med Res Opin. 2002; 18: 220-228
        • Bountioukos M.
        • Rizzello V.
        • Krenning B.J.
        • Bax J.J.
        • Kertai M.D.
        • Vourvouri E.C.
        • Schinkel A.F.
        • Biagini E.
        • Boersma E.
        • Roelandt J.R
        • et al.
        Effect of atorvastatin on myocardial contractile reserve assessed by tissue Doppler imaging in moderately hypercholesterolemic patients without heart disease.
        Am J Cardiol. 2003; 92: 613-616
        • Langsjoen P.H.
        • Langsjoen P.H.
        • Folkers K.
        Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment.
        Clin Invest. 1993; 71: S140-S144
        • Oda T.
        Recovery of load-induced left ventricular diastolic dysfunction by coenzyme Q10: echocardiographic study.
        Mol Aspects Med. 1994; 15: S149-S154