We compared brain natriuretic peptide (BNP) levels in patients with obstructive sleep
apnea (OSA) with and without cardiovascular disease to BNP in healthy control subjects.
OSA was not associated with increased plasma BNP or atrial natriuretic peptide (ANP)
in otherwise healthy subjects during wakefulness. Untreated OSA increased ANP overnight,
and ANP levels decreased with treatment of OSA. However, OSA did not elicit acute
overnight changes in BNP, either in normal subjects or in patients with coexisting
cardiovascular disease (including chronic heart failure).
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Article Info
Publication History
Accepted:
May 3,
2004
Received:
February 4,
2004
Footnotes
This study was supported by Grants HL-65176, HL-61560, HL-70602, and M01-RR00585 from the National Institutes of Health, Bethesda, Maryland.
Identification
Copyright
© 2004 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
