Steven Evan Nissen, MD: A conversation with the editor*

        Steve Nissen is the medical director of the Cardiovascular Coordinating Center, The Cleveland Clinic Foundation, and Vice President of the American College of Cardiology. He was born in Toledo, Ohio, in September 1948. He graduated from the University of Michigan in 1974 and from the University of Michigan School of Medicine in Ann Arbor in 1978. His internship and residency in internal medicine were at the University of California, Davis, in Sacramento, and his fellowship in cardiology was at the University of Kentucky Medical Center in Lexington. After completion of his fellowship in 1983, he remained on the faculty at the University of Kentucky College of Medicine until 1992, when he moved to Cleveland to be the director of the coronary intensive care unit at The Cleveland Clinic Foundation. He has published over 100 articles in peer-reviewed medical journals and about 40 chapters in various cardiology books. Dr. Nissen is the “father” of intravascular ultrasonic imaging of the coronary arteries and his pioneering work in this area has opened multiple channels for learning about the atherosclerotic process and for evaluating antiatherosclerotic drugs. He presently is on the Cardio-Renal Advisory Panel of the US Food and Drug Administration (Figure 1).
        Figure thumbnail GR1
        FIGURE 1SN at time of interview.
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        Further reading

        Best publications as listed by SEN
        Numbered by date order, not as on CV.
        *Numbered by date order, not as on CV.

        1. Nissen SE, Booth DC, Waters J, Fassas T, DeMaria AN. Evaluation of left ventricular contractile pattern by intravenous digital subtraction ventriculography: comparison with cineangiography and assessment of interobserver variability. Am J Cardiol1983;53:1293–1298.

        2. Nissen SE, Elion J, Booth DC, Evans J, DeMaria A. Value and limitations of computer analysis of digital subtraction angiography in the assessment of coronary flow reserve. Circulation1986;73:562–571.

        3. Nissen SE, Grines CL, Gurley JC, Sublett K, Haynie D, Diaz C, Booth DC, DeMaria AN. Application of a new phased-array ultrasound catheter in the assessment of vascular dimensions: in-vivo comparison to cineangiography. Circulation 1990;82:660–666.

        4. Nissen SE, Gurley JC. Assessment of the functional significance of coronary stenoses: is digital angiography the answer? Circulation 1990;1:1431–1435.

        5. Nissen SE, Gurley JC, Grines CL, Booth DC, McClure RA, Berk MA, Fischer C, DeMaria AN. Intravascular ultrasound assessment of lumen size and wall morphology in normal subjects and coronary artery disease patients. Circulation 1991;84:1087–1099.

        6. Nissen SE, Ritchie JL, Douglas JS, Dreifus LS, Gibbons RJ, Higgins CB, Schelbert HR, Seward JB, Zaret BL. ACC position statement: use of nonionic or low osmolar contrast agents in cardiovascular procedures. J Am Coll Cardiol 1993;21:269–273.

        7. Nissen SE, Pepine CJ, Block PC, Brinker J, Douglas, JS, Johnson WL, Klinke WP, Levin DC, Mullins C, Topol EJ, Ullyot DJ, Vetrovic GW, Vogel JH. Cardiac angiography without cine film: erecting a “Tower of Babel” in the catheterization laboratory. J Am Coll Cardiol 1994;24:834–837.

        8. Topol EJ, Nissen SE. Our preoccupation with coronary luminology. The dissociation between clinical and angiographic findings in ischemic heart disease. Circulation 1995;92:2333–2342.

        9. Scanlon PF, Faxon DP, Audet AM, Carabello B, Dehmer GJ, Eagle KA, Legako RD, Leon DE, Murray JA, Nissen SE, Pepine CJ, Watson RM, Ritchie FL, Gibbons RJ, Chetlin MD, Gardner TJ, Garson A Jr., Russell RO Fr., Ryan TJ, Smith SC Jr. ACC/AHA Guidelines for Coronary Angiography: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography). Developed in collaboration with the Society for Cardiac Angiography and Interventions. J Am Coll Cardiol 1999;33:1756–1824; and Circulation 1999;4;99:2345–2357.

        10. Kerensky RA, Cusma JT, Kubilis P, Rüdiger S, Bashore TM, Hirshfeld JW, Holmes DR, Pepine CJ, Nissen SE. American College of Cardiology and European Society of Cardiology International Study of Angiographic Data Compression Phase I “The effects of lossy data compression on the recognition of diagnostic features in digital coronary angiography.” J Am Coll Cardiol 2000;35:1370–1379.

        11. Nissen SE, Yock P. Intravascular ultrasound: novel diagnostic insights and current clinical applications. Circulation 2001;103:604–616.

        12. Mintz G. Nissen SE, Anderson WD, Bailey SR, Erberl R, Fitzgerald P, Pinto FJ, Rosenfield K, Seigel RJ, Tuzcu EM, Yock PG. Standards for the acquisition measurement and reporting of intravascular ultrasound studies. J Am Coll Cardiol 2001;37:1478–1492.

        13. Tuzcu EM, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM, Young JB, Nissen SE. High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound. Circulation 2001;103:2705–2710.

        14. Mukherjee D, Nissen SE, Topol EJ. Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA 2001;286:954–959.

        15. Khot UN, Novaro GM, Popovic ZB, Mills RM, Thomas FD, Tuzcu EM, Hammer D, Nissen SE, Francis GS. Nitroprusside in critically ill patients with left ventricular dysfunction and aortic stenosis. N Engl J Med 2003;348:1756–1763.

        16. Khott U, Nissen SE. Is ‘CURE’ a cure for acute coronary syndromes? Statistical versus clinical significance. J Am Coll Cardiol 2002;40:218–219.

        17. Nissen SE. Pathobiology, not angiography, should guide management in acute coronary syndrome/non-ST-segment elevation myocardial infarction: The non-interventionist's perspective. J Am Coll Cardiol 2003;41:103–112.

        18. Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, Eaton GM, Lauer MA, Sheldon WS, Grines CL, Halpern Stephen, Crowe TD, Blankenship JC, Kerensky R.Effect of recombinant ApoA-1 Milano on coronary atherosclerosis in patients with acute coronary syndromes. JAMA 2003;290:2292–2300.

        19. Nissen SE, Tuzcu EM, Brown BG, Schoenhagen P, DeMaria AN, Cooper CT, Ganz P, Grines CL, Brodie B, Vogel RA, Crowe TD, Howard G. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis—a randomized controlled trial. JAMA 2004;291:1071–1080.

        20. Brennan ML, Penn MS, Van Lente F, Nambi V, Shishehbor MH, Aviles RJ, Goormastic M, Pepoy ML, McErlean ES, Topol EJ, Nissen SE, Hazen SL. Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 2003;349:1595–1604.