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Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively

      Abstract

      We performed an observational study on 137 patients undergoing carotid endarterectomy (CEA). Patients on statins were less likely to have had symptoms in the 4 weeks before CEA (p = 0.0049) and were less likely to have spontaneous cerebral embolization detected by transcranial Doppler (p = 0.0459). Carotid plaques retrieved at CEA from patients taking statins revealed significantly lower concentrations of matrix metalloproteinase-1 (p = 0.0176), matrix metalloproteinase-9 (p = 0.0018), and interleukin-6 (p = 0.0005).
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      References

        • Heart Protection Study Collaborative Group
        MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals.
        Lancet. 2002; 360: 7-22
        • Smith J.L
        • Evans D.H
        • Fan L
        • Gaunt M.E
        • London N.J
        • Bell P.R.F
        • Naylor A.R
        Interpretation of embolic phenomena during carotid endarterectomy.
        Stroke. 1995; 26: 2281-2284
        • Vine N
        • Powell J.T
        Metalloproteinases in degenerative aortic disease.
        Clin Sci (Lond). 1991; 81: 233-239
        • Crisby M
        • Nordin-Fredriksson G
        • Shah P.K
        • Yano J
        • Zhu J
        • Nilsson J
        Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques.
        Circulation. 2001; 103: 926-933
        • Sukhova G.K
        • Schonbeck U
        • Rabkin E
        • Schoen F.J
        • Poole A.R
        • Billinghurst R.C
        • Libby P
        Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.
        Circulation. 1999; 99: 2503-2509
        • Loftus I.M
        • Naylor A.R
        • Goodall S
        • Crowther M
        • Jones L
        • Bell P.R.F
        • Thompson M.M
        Increased matrix metalloproteinase-9 activity in unstable carotid plaques.
        Stroke. 2000; 31: 40-47
        • Biasucci L.M
        • Vitelli A
        • Liuzzo G
        • Altamura S
        • Caligiuri G
        • Monaco C
        • Rebuzzi A.G
        • Ciliberto G
        • Maseri A
        Elevated levels of interleukin-6 in unstable angina.
        Circulation. 1996; 94: 874-877
        • Fenton Jr., J.W
        • Shen G.X
        Statins as cellular antithrombotics.
        Haemostasis. 1999; 29: 166-169