We performed an observational study on 137 patients undergoing carotid endarterectomy (CEA). Patients on statins were less likely to have had symptoms in the 4 weeks before CEA (p = 0.0049) and were less likely to have spontaneous cerebral embolization detected by transcranial Doppler (p = 0.0459). Carotid plaques retrieved at CEA from patients taking statins revealed significantly lower concentrations of matrix metalloproteinase-1 (p = 0.0176), matrix metalloproteinase-9 (p = 0.0018), and interleukin-6 (p = 0.0005).
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Accepted: March 19, 2004
Received in revised form: March 19, 2004
Received: November 20, 2003
☆This study was funded by the United Kingdom Stroke Association, London, United Kingdom.
© 2004 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.