Effect of left ventricular remodeling after cardiac resynchronization therapy on frequency of ventricular arrhythmias


      We evaluated whether cardiac resynchronization therapy affects the prevalence of ventricular tachycardia in relation to reverse remodeling in patients with end-stage heart failure. Clinical, echocardiographic, and implantable cardioverter-defibrillator (ICD) data of 17 patients with ICDs were obtained before and after they had received an upgrade to an ICD-cardiac resynchronization therapy device.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Higgins S.L
        • Yong P
        • Sheck D
        • McDaniel M
        • Bollinger F
        • Vadecha M
        • Desai S
        • Meyer D.B
        Biventricular pacing diminishes the need for implantable cardioverter defibrillator therapy. Ventak CHF Investigators.
        J Am Coll Cardiol. 2000; 36: 824-827
        • Martinelli F.M
        • Pedrosa A.A
        • Costa R
        • Nishioka S.A
        • Siqueira S.F
        • Tamaki W.T
        • Sosa E
        Biventricular pacing improves clinical behavior and reduces prevalence of ventricular arrhythmia in patients with heart failure.
        Arq Bras Cardiol. 2002; 78: 110-113
        • Walker S
        • Levy T.M
        • Rex S
        • Brant S
        • Allen J
        • Ilsley C.J
        • Paul V.E
        Usefulness of suppression of ventricular arrhythmia by biventricular pacing in severe congestive cardiac failure.
        Am J Cardiol. 2000; 86: 231-333
        • Zagrodzky J.D
        • Ramaswamy K
        • Page R.L
        • Joglar J.A
        • Sheehan C.J
        • Smith M.L
        • Hamdan M.H
        Biventricular pacing decreases the inducibility of ventricular tachycardia in patients with ischemic cardiomyopathy.
        Am J Cardiol. 2001; 87: 1208-1210
        • Stellbrink C
        • Breithardt O.A
        • Franke A
        • Sack S
        • Bakker P
        • Auricchio A
        • Pochet T
        • Salo R
        • Kramer A
        • Spinelli J
        • PATH-CHF Investigators, CPI Guidant Congestive Heart Failure Research Group
        Impact of cardiac resynchronization therapy using hemodynamically optimized pacing on left ventricular remodeling in patients with congestive heart failure and ventricular conduction disturbances.
        J Am Coll Cardiol. 2001; 38: 1957-1965
        • Alonso C
        • Leclercq C
        • Victor F
        • Mansour H
        • de Place C
        • Pavin D
        • Carré F
        • Mabo P
        • Daubert J.C
        Electrocardiographic predictive factors of long-term clinical improvement with multisite biventricular pacing in advanced heart failure.
        Am J Cardiol. 1999; 84: 1417-1421
        • Butter C
        • Auricchio A
        • Stellbrink C
        • Fleck E
        • Ding J
        • Yu Y
        • Huvelle E
        • Spinelli J
        Effect of resynchronization therapy stimulation site on the systolic function of heart failure patients.
        Circulation. 2001; 104: 3026-3029
        • Rector T.S
        • Kubo S.H
        • Cohn J.N
        Validity of the Minnesota Living with Heart Failure questionnaire as a measure of therapeutic response to enalapril or placebo.
        Am J Cardiol. 1993; 71: 1106-1107
        • Lipkin D.P
        • Scriven A.J
        • Crake T
        • Poole-Wilson P.A
        Six minute walking test for assessing exercise capacity in chronic heart failure.
        Br Med J (Clin Res Ed). 1986; 292: 653-655
        • Schiller N.B
        • Shah P.M
        • Crawford M
        • DeMaria A
        • Devereux R
        • Feigenbaum H
        • Gutgesell H
        • Reichek N
        • Sahn D
        • Schnittger I
        Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms.
        J Am Soc Echocardiogr. 1989; 2: 358-367
        • Feigenbaum H
        Echocardiography in the management of mitral valve prolapse.
        Aust NZ J Med. 1992; 22: 550-555
        • Heinle S.K
        • Grayburn P.A
        Doppler echocardiographic assessment of mitral regurgitation.
        Coron Artery Dis. 2000; 11: 11-18
        • St John Sutton M
        • Lee D
        • Rouleau J.L
        • Goldman S
        • Plappert T
        • Braunwald E
        • Pfeffer M.A
        Left ventricular remodeling and ventricular arrhythmias after myocardial infarction.
        Circulation. 2003; 107: 2577-2582