Usefulness of quantitative gated single-Photon emission computed tomography to evaluate ventricular synchrony in patients receiving biventricular pacing


      Quantitative gated single-photon emission computed tomography was performed in 10 patients before and shortly after (<1 month) receiving biventricular pacing (BVP). They were divided into 2 groups (responder and nonresponder groups) on the basis of clinical status and echocardiographic parameters 18 ± 6 months later. In the responder group, left ventricular synchrony shortly after BVP improved significantly compared with that before BVP (p <0.05), but there was no change in the nonresponder group.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Abraham W.T
        • Hayes D.L
        Cardiac resynchronization therapy for heart failure.
        Circulation. 2003; 108: 2596-2603
        • Kass D.A
        Ventricular resynchronization.
        Rev Cardiovasc Med. 2003; 4: S3-S13
        • Schuster P
        • Faerestrand S
        • Ohm O.J
        Colour tissue velocity imaging can show resynchronisation of longitudinal left ventricular contraction pattern by biventricular pacing in patients with severe heart failure.
        Heart. 2003; 89: 859-864
        • Sogaard P
        • Egeblad H
        • Kim W.Y
        • Jensen H.K
        • Pedersen A.K
        • Kristensen B.O
        • Mortensen P.T
        Tissue Doppler imaging predicts improved systolic performance and reversed left ventricular remodeling during long-term cardiac resynchronization therapy.
        J Am Coll Cardiol. 2002; 40: 723-730
        • Yu C.M
        • Chau E
        • Sanderson J.E
        • Fan K
        • Tang M.O
        • Fung W.H
        • Lin H
        • Kong S.L
        • Lam Y.M
        • Hill M.R
        • Lau C.P
        Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure.
        Circulation. 2002; 105: 438-445
        • Leclercq C
        • Faris O
        • Tunin R
        • Johnson J
        • Kato R
        • Evans F
        • Spinelli J
        • Halperin H
        • McVeigh E
        • Kass D.A
        Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block.
        Circulation. 2002; 106: 1760-1763
        • Germano G
        • Kiat H
        • Kavanagh P.B
        • Moriel M
        • Mazzanti M
        • Su H.T
        • Van Train K.F
        • Berman D.S
        Automatic quantification of ejection fraction from gated myocardial perfusion SPECT.
        J Nucl Med. 1995; 36: 2138-2147
        • Berman D.S
        • Germano G
        Evaluation of ventricular ejection fraction, wall motion, wall thickening, and other parameters with gated myocardial perfusion single-photon emission computed tomography.
        J Nucl Cardiol. 1997; 4: S169-S171
        • Yoshioka J
        • Hasegawa S
        • Yamaguchi H
        • Tokita N
        • Paul A.K
        • Xiuli M
        • Maruyama A
        • Hori M
        • Nishimura T
        Left ventricular volumes and ejection fraction calculated from quantitative electrocardiographic-gated 99mTc-tetrofosmin myocardial SPECT.
        J Nucl Med. 1999; 40: 1693-1698
        • Atsma D.E
        • Bavelaar-Croon C.D
        • Germano G
        • Dibbets-Schneider P
        • van Eck-Smit B.L
        • Pauwels E.K
        • van der Wall E.E
        Good correlation between gated single photon emission computed myocardial tomography and contrast ventriculography in the assessment of global and regional left ventricular function.
        Int J Card Imaging. 2000; 16: 447-453
        • Vourvouri E.C
        • Poldermans D
        • Bax J.J
        • Sianos G
        • Sozzi F.B
        • Schinkel A.F
        • de Sutter J
        • Parcharidis G
        • Valkema R
        • Roelandt J.R
        Evaluation of left ventricular function and volumes in patients with ischaemic cardiomyopathy.
        Eur J Nucl Med. 2001; 28: 1610-1615
        • Schiller N.B
        Two-dimensional echocardiographic determination of left ventricular volume, systolic function, and mass. Summary and discussion of the 1989 recommendations of the American Society of Echocardiography.
        Circulation. 1991; 84: I280-I287