Serum C-reactive protein and lipids in ultra-Marathon runners


      In this investigation, we compared lipid and inflammatory parameters in regular long distance runners with matched sedentary controls. Long distance runners had significantly lower low-density lipoprotein cholesterol and C-reactive protein levels than the control group. This exercise-induced reduction in low-density lipoprotein cholesterol was independent of the decrease in C-reactive protein levels.
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        • Tomaszewski M
        • Charchar F.J
        • Przybycin M
        • Crawford L
        • Wallace A.M
        • Gosek K
        • Lowe G.D
        • Zukowska-Szczechowska E
        • Grzeszczak W
        • Sattar N
        • Dominiczak A.F
        Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity. How low can you go?.
        Arterioscler Thromb Vasc Biol. 2003; 23: 1640-1644
        • Charchar F.J
        • Tomaszewski M
        • Lacka B
        • Zakrzewski J
        • Zukowska-Szczechowska E
        • Grzeszczak W
        • Dominiczak A.F
        Association of the human Y chromosome with cholesterol levels in the general population.
        Arterioscler Thromb Vasc Biol. 2004; 24: 308-312
        • Vodak P.A
        • Wood P.D
        • Haskell W.L
        • Williams P.T
        HDL-cholesterol and other plasma lipid and lipoprotein concentrations in middle-aged male and female tennis players.
        Metabolism. 1980; 29: 745-752
        • Haluzik M
        • Boudova L
        • Nedvidkova J
        • Haluzikova D
        • Barackova M
        • Brandejsky P
        • Vilikus Z
        Lower serum leptin concentrations in rugby players in comparison with healthy non-sporting subjects—relationships to anthropometric and biochemical parameters.
        Eur J Appl Physiol Occup Physiol. 1998; 79: 58-61
        • Kraus W.E
        • Houmard J.A
        • Duscha B.D
        • Knetzger K.J
        • Wharton M.B
        • McCartney J.S
        • Bales C.W
        • Henes S
        • Samsa G.P
        • Otvos J.D
        • Kulkarni K.R
        • Slentz C.A
        Effects of the amount and intensity of exercise on plasma lipoproteins.
        N Engl J Med. 2002; 347: 1483-1492
        • Ziccardi P
        • Nappo F
        • Giugliano G
        • Esposito K
        • Marfella R
        • Cioffi M
        • D'Andrea F
        • Molinari A.M
        • Giugliano D
        Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year.
        Circulation. 2002; 105: 804-809
        • Plenge J.K
        • Hernandez T.L
        • Weil K.M
        • Poirier P
        • Grunwald G.K
        • Marcovina S.M
        • Eckel R.H
        Simvastatin lowers C-reactive protein within 14 days. An effect independent of low-density lipoprotein cholesterol reduction.
        Circulation. 2002; 106: 1447-1452
        • Albert M.A
        • Danielson E
        • Rifai N
        • Ridker P.M
        Effect of statin therapy on C-reactive protein levels.
        JAMA. 2001; 286: 64-70
        • Ridker P.M
        • Rifai N
        • Lowenthal S.P
        Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia.
        Circulation. 2001; 103: 1191-1193
        • Weitz-Schmidt G
        Statins as anti-inflammatory agents.
        Trends Pharmacol Sci. 2002; 23: 482-486