Relation between depressive symptoms and treadmill exercise capacity in the Heart and Soul Study

  • Bernice Ruo
    Dr. Ruo's address is: Northwestern University, Feinberg School of Medicine, 680 North St. Clair, Chicago, Illinois 60611, USA.
    Section of General Internal Medicine, VA Medical CenterSan Francisco, California, USA

    Department of Medicine, University of California, San Francisco, California, USA
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  • John S Rumsfeld
    Cardiology and Health Services Research, Denver Veterans Affairs Medical Center, Denver, Colorado; and Department of Medicine, Northwestern University, Chicago, Illinois, USA
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  • Sharon Pipkin
    Section of General Internal Medicine, VA Medical CenterSan Francisco, California, USA
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  • Mary A Whooley
    Section of General Internal Medicine, VA Medical CenterSan Francisco, California, USA

    Department of Medicine, University of California, San Francisco, California, USA

    Department ofEpidemiology and Biostatistics, University of California, San Francisco, California, USA
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      To examine the association between depressive symptoms and exercise capacity, we performed a cross-sectional study of 944 outpatients with stable coronary artery disease and found that the presence of depressive symptoms was independently associated with poor exercise capacity (<5 MET tasks achieved; adjusted odds ratio 1.8, 95% confidence interval 1.1 to 2.7, p = 0.01). Depressive symptoms should be considered in the differential diagnosis of poor exercise capacity.
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