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Relation between depressive symptoms and treadmill exercise capacity in the Heart and Soul Study

  • Bernice Ruo
    Correspondence
    Dr. Ruo's address is: Northwestern University, Feinberg School of Medicine, 680 North St. Clair, Chicago, Illinois 60611, USA.
    Affiliations
    Section of General Internal Medicine, VA Medical CenterSan Francisco, California, USA

    Department of Medicine, University of California, San Francisco, California, USA
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  • John S Rumsfeld
    Affiliations
    Cardiology and Health Services Research, Denver Veterans Affairs Medical Center, Denver, Colorado; and Department of Medicine, Northwestern University, Chicago, Illinois, USA
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  • Sharon Pipkin
    Affiliations
    Section of General Internal Medicine, VA Medical CenterSan Francisco, California, USA
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  • Mary A Whooley
    Affiliations
    Section of General Internal Medicine, VA Medical CenterSan Francisco, California, USA

    Department of Medicine, University of California, San Francisco, California, USA

    Department ofEpidemiology and Biostatistics, University of California, San Francisco, California, USA
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      Abstract

      To examine the association between depressive symptoms and exercise capacity, we performed a cross-sectional study of 944 outpatients with stable coronary artery disease and found that the presence of depressive symptoms was independently associated with poor exercise capacity (<5 MET tasks achieved; adjusted odds ratio 1.8, 95% confidence interval 1.1 to 2.7, p = 0.01). Depressive symptoms should be considered in the differential diagnosis of poor exercise capacity.
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      References

        • Ruo B
        • Rumsfeld J.S
        • Hlatky M.A
        • Liu H
        • Browner W.S
        • Whooley M.A
        Depressive symptoms and health-related quality of life.
        JAMA. 2003; 290: 215-221
        • Myers J
        • Prakash M
        • Froelicher V
        • Do D
        • Partington S
        • Atwood J.E
        Exercise capacity and mortality among men referred for exercise testing.
        N Engl J Med. 2002; 346: 793-801
        • Kroenke K
        • Spitzer R.L
        • Williams J.B
        The PHQ-9.
        J Gen Intern Med. 2001; 16: 606-613
      1. Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. American Psychiatric Association, Washington, DC1994
        • Spertus J.A
        • Winder J.A
        • Dewhurst T.A
        • Deyo R.A
        • Prodzinski J
        • McDonell M
        • Fihn S.D
        Development and evaluation of the Seattle Angina Questionnaire.
        J Am Coll Cardiol. 1995; 25: 333-341
        • Schiller N.B
        • Shah P.M
        • Crawford M
        • DeMaria A
        • Devereux R
        • Feigenbaum H
        • Gutgesell H
        • Reichek N
        • Sahn D
        • Schnittger I
        Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms.
        J Am Soc Echocardiogr. 1989; 2: 358-367
        • Gibbons R.J
        • Balady G.J
        • Bricker J.T
        • Chaitman B.R
        • Fletcher G.F
        • Froelicher V.F
        • Mark D.B
        • McCallister B.D
        • Mooss A.N
        • O'Reilly M.G
        • et al.
        ACC/AHA 2002 guideline update for exercise testing.
        Circulation. 2002; 106: 1883-1892
        • Inouye S.K
        • Peduzzi P.N
        • Robison J.T
        • Hughes J.S
        • Horwitz R.I
        • Concato J
        Importance of functional measures in predicting mortality among older hospitalized patients.
        JAMA. 1998; 279: 1187-1193
        • Gardner S.C
        • Grunwald G.K
        • Rumsfeld J.S
        • Mackenzie T
        • Gao D
        • Perlin J.B
        • McDonald G
        • Shroyer A.L.G
        Risk factors for intermediate-term survival after coronary artery bypass grafting.
        Ann Thorac Surg. 2001; 72: 2033-2037
        • Ades P.A
        • Maloney A
        • Savage P
        • Carhart Jr, R.L
        Determinants of physical functioning in coronary patients.
        Arch Intern Med. 1999; 159: 2357-2360
        • Kempen G.I
        • Sullivan M
        • van Sonderen E
        • Ormel J
        Performance-based and self-reported physical functioning in low-functioning older persons.
        J Gerontol B Psychol Sci Soc Sci. 1999; 54: 380-386
        • Haelan W.R
        • Parsons P.E
        • Thomas J.W
        • Murt H.A
        • Lepkowski J.M
        • Guire K.E
        Health care utilization and costs of adult cardiovascular conditions.
        Natl Med Care Util Expend Surv C. 1987; 7: 1-69
        • Miller M.D
        • Schulz R
        • Paradis C
        • Houck P.R
        • Mazumdar S
        • Frank E
        • Dew M.A
        • Reynolds III, C.F
        Changes in perceived health status of depressed elderly patients treated until remission.
        Am J Psychiatry. 1996; 153: 1350-1352
        • Cossette S
        • Frasure-Smith N
        • Lesperance F
        Clinical implications of a reduction in psychological distress on cardiac prognosis in patients participating in a psychosocial intervention program.
        Psychosom Med. 2001; 63: 257-266
        • Rumsfeld J.S
        • MaWhinney S
        • McCarthy Jr, M
        • Shroyer A.L
        • VillaNueva C.B
        • O'Brien M
        • Moritz T.E
        • Henderson W.G
        • Grover F.L
        • Sethi G.K
        • Hammermeister K.E
        Health-related quality of life as a predictor of mortality following coronary artery bypass graft surgery. Participants of the Department of Veterans Affairs Cooperative Study Group on Processes, Structures, and Outcomes of Care in Cardiac Surgery.
        JAMA. 1999; 281: 1298-1303
        • Spertus J.A
        • Jones P
        • McDonell M
        • Fan V
        • Fihn S.D
        Health status predicts long-term outcome in outpatients with coronary disease.
        Circulation. 2002; 106: 43-49
        • Idler E.L
        • Angel R.J
        Self-rated health and mortality in the NHANES-I Epidemiologic Follow-up Study.
        Am J Public Health. 1990; 80: 446-452
        • Sauer W.H
        • Berlin J.A
        • Kimmel S.E
        Selective serotonin reuptake inhibitors and myocardial infarction.
        Circulation. 2001; 104: 1894-1898
        • Serebruany V.L
        • Glassman A.H
        • Malinin A.I
        • Nemeroff C.B
        • Musselman D.L
        • van Zyl L.T
        • Finkel M.S
        • Krishnan K.R
        • Gaffney M
        • Harrison W
        • et al.
        • Sertraline AntiDepressant Heart Attack Randomized Trial Study Group
        Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events.
        Circulation. 2003; 108: 939-944
        • Glassman A.H
        • O'Connor C.M
        • Califf R.M
        • Swedberg K
        • Schwartz P
        • Bigger Jr, J.T
        • Krishnan K.R
        • van Zyl L.T
        • Swenson J.R
        • Finkel M.S
        • et al.
        • Sertraline Antidepressant Heart Attack Randomized Trial (SADHART) Group
        Sertraline treatment of major depression in patients with acute MI or unstable angina.
        JAMA. 2002; 288: 701-709