Abstract
We tested the hypothesis that myocardial microvascular abnormalities occur and are
influenced by clinical features in 30 patients with hypertrophic cardiomyopathy (HC)
using intravenous myocardial contrast echocardiography. Patients with HC were subdivided
into 3 groups: nonobstructive HC (n = 12), obstructive HC (n = 10), or HC with systolic
dysfunction and heart failure (n = 8). In patients with nonobstructive HC and obstructive
HC, subendocardial peak myocardial contrast intensity at the mid-septal area was significantly
decreased and the transmyocardial difference of peak myocardial contrast intensity
between subendocardial and periendocardial regions at the mid-septal area was significantly
related to regional wall thickness. Reduced peak myocardial contrast intensities at
the mid-septal subendocardial and periendocardial regions were observed in patients
with HC and heart failure. Our study indicates that subendocardial microvascular abnormalities
during end-systole may be associated with severity of regional myocardial hypertrophy
in patients with nonobstructive HC and obstructive HC. In addition, progressive microvascular
damage may occur in patients with HC and heart failure.
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Article info
Publication history
Accepted:
March 19,
2004
Received in revised form:
March 19,
2004
Received:
January 13,
2004
Identification
Copyright
© 2004 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
