In a recent issue of this journal, Fujiki et al
1reported on their experience with bepridil, a potassium channel blocker, for conversion of long-lasting atrial fibrillation (AF) in 32 patients. The authors determined atrial cycle length during AF from the surface electrocardiogram at baseline and after drug administration using frequency analysis techniques, and correlated changes in atrial cycle length with conversion success. In short, this method disregards the electrical activity of the ventricles by QRST canceling and uses fast-Fourier transformation to identify the frequency content of the fibrillating atria. The authors find a greater cycle length increase in responders than in nonresponders. Although their results are both interesting and sound from a pathophysiologic point of view, their data analysis contains an important error.
- Fujiki A
- Tsuneda T
- Sugao M
- Mizumaki K
- Inoue H
Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm.
Am J Cardiol. 2003; 92: 472-475
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- Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm.Am J Cardiol. 2003; 92: 472-475
- Frequency analysis of human atrial fibrillation using the surface electrocardiogram and its response to ibutilide.Am J Cardiol. 1998; 81: 1439-1445
- Importance of left atrial diameter and atrial fibrillatory frequency for conversion of persistent atrial fibrillation with oral flecainide.Am J Cardiol. 2002; 90: 1011-1014
- Frequency measures obtained from the surface electrocardiogram in atrial fibrillation research and clinical decision-making.J Cardiovasc Electrophysiol. 2003; 14: S154-S161
- A classification of atrial flutter and regular atrial tachycardia according to electrophysiological mechanisms and anatomical bases.Eur Heart J. 2001; 22: 1162-1182
Received: February 10, 2004
© 2004 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.