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Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart disease

      Previous studies using Doppler and M-mode echocardiography have demonstrated that abnormalities of left ventricular (LV) diastolic relaxation are sensitive markers of early myocardial dysfunction. Tissue Doppler echocardiography and color M-mode propagation velocity (Vp) are novel noninvasive techniques that provide an estimate of LV relaxation
      • Garcia M.J.
      • Ares M.A.
      • Asher C.
      • Rodriguez L.
      • Vandervoort P.
      • Thomas J.D.
      An index of early left ventricular filling that combined with pulsed Doppler peak E velocity may estimate capillary wedge pressure.
      ,
      • Garcia M.J.
      • Rodriguez L.
      • Ares M.
      • Griffin B.P.
      • Klein A.L.
      • Stewart W.J.
      • Thomas J.D.
      Myocardial wall velocity assessment by pulsed Doppler tissue imaging characteristic findings in normal subjects.
      ,
      • Garcia M.J.
      • Thomas J.D.
      • Klein A.L.
      New Doppler echocardiographic applications for the study of diastolic function.
      and are less dependent on preload.
      • Nagueh S.F.
      • Middleton K.J.
      • Kopelen H.A.
      • Zoghbi W.A.
      • Quinones M.A.
      Doppler tissue imaging a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures.
      ,
      • Sohn D.W.
      • Chai I.H.
      • Lee D.J.
      • Kim H.C.
      • Kim H.S.
      • Oh B.H.
      • Lee M.M.
      • Park Y.B.
      • Choi Y.S.
      • Seo J.D.
      • Lee Y.W.
      Assessment of mitral annulus velocity by Doppler tissue imaging in the evaluation of left ventricular diastolic function.
      Furthermore, mitral inflow early filling (E) can be used in conjunction with tissue Doppler echocardiography early diastolic velocity (EM) and Vp to estimate LV filling pressures.
      • Garcia M.J.
      • Thomas J.D.
      • Klein A.L.
      New Doppler echocardiographic applications for the study of diastolic function.
      ,
      • Nagueh S.F.
      • Middleton K.J.
      • Kopelen H.A.
      • Zoghbi W.A.
      • Quinones M.A.
      Doppler tissue imaging a noninvasive technique for evaluation of left ventricular relaxation and estimation of filling pressures.
      The present study examines whether subclinical diastolic dysfunction is found in asymptomatic type 1 diabetic patients, and evaluates the relation between diastolic dysfunction and glycemic control using novel echocardiographic techniques.
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