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Prognostic significance of heart rate turbulence in patients undergoing coronary artery bypass grafting

      Coronary artery bypass grafting (CABG) has been documented to decrease the risk of cardiac and sudden death by improving the blood supply and thus decreasing myocardial ischemia and the arrhythmogenic substrate.
      • Holmes D.R.
      • Davis K.B.
      • Mock M.B.
      • Fisher L.D.
      • Gersh B.J.
      • Killip T.
      • Pettinger M.
      The effect of medical and surgical treatment on subsequent sudden cardiac death patients with coronary artery disease a report from the Coronary Artery Surgery Study.
      ,
      • Varnauskas E.
      Survival, myocardial infarction and employment status in a prospective randomized study of coronary bypass surgery.
      ,
      • Guiraudon G.M.
      Coronary artery bypass grafting in the management of ventricular arrhythmias in patients with coronary artery disease.
      Noninvasive parameters including late potentials and heart rate variability have been used to predict cardiac events in coronary patients. There are limited data regarding the prognostic significance of these parameters when evaluated before CABG.
      The CABG Patch Trial Investigators and Coordinators
      The Coronary Artery Bypass Graft (CABG) Patch Trial.
      ,
      • Kleiger R.E.
      • Miller J.P.
      • Bigger Jr, J.T.
      • Moss A.
      the Multicenter Post- Infarction Research Group
      Decreased heart rate variability and its association with increased mortality after acute myocardial infarction.
      Heart rate turbulence (HRT), which reflects a response of heart rate to a premature ventricular beat, is a new, noninvasive electrocardiographic predictor of cardiac death.
      • Schmidt G.
      • Malik M.
      • Barthel P.
      • Schneider R.
      • Ulm K.
      • Rolnitzky L.
      • Camm A.J.
      • Bigger Jr, J.T.
      • Schömig A.
      Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction.
      ,
      • Mrowka R.
      • Persson P.B.
      • Theres H.
      • Patzak A.
      Blunted arterial baroreflex causes “pathological” heart rate turbulence.
      ,
      • Ghuran A.
      • Reid F.
      • La Rovere M.T.
      • Schmidt G.
      • Bigger J.T.
      • Camm A.J.
      • Schwartz P.J.
      • Malik M.
      ATRAMI Investigators
      Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The Autonomic Tone and Reflexes After Myocardial Infarction substudy).
      There are no data concerning the prognostic value of HRT parameters in patients undergoing CABG. This study evaluates the prognostic significance of HRT parameters for predicting cardiac death in patients undergoing CABG.
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