The relationship between the heart and the liver is well established.
1
Therefore, it is surprising that the pattern of liver dysfunction in heart failure
has only been defined recently. Lau and colleagues
2
reported in this journal that heart failure is characterized by a cholestatic liver
enzyme profile with elevated serum alkaline phosphatase (SAP) and γ-glutamyl transferase
(GGT). The severity of cholestasis correlated with degree of tricuspid incompetence,
pulmonary hypertension, and left ventricular ejection fraction. The histopathologic
characteristics of the liver in heart failure were also described, including hyperaemia
and congestion of the centrolobular zone of the hepatic lobule and collagen deposition
and fibrosis of the septa.To read this article in full you will need to make a payment
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References
- Heart diseases affecting the liver and liver disease affecting the heart.Am Heart J. 2000; 140: 111-120
- Type of liver dysfunction in heart failure and its relation to the severity of tricuspid regurgitation.Am J Cardiol. 2002; 90: 1405-1408
- AGA technical review on the evaluation of liver chemistry tests.Gastroenterology. 2002; 123: 1367-1384
- High perfusion pressure damages the sieving ability of sinusoidal endothelium in rat livers.Br J Exp Path. 1980; 61: 222-228
- The morphologic characteristics of intercellular junctions between normal human liver cells and cells from patients with extrahepatic cholestasis.Am J Pathol. 1980; 100: 93-114
- Hepatic pseudocapillarisation and atherosclerosis in ageing.Lancet. 2002; 359: 1612-1615
Article info
Publication history
Received:
February 10,
2003
Identification
Copyright
© 2003 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
