Advertisement
The American Journal of Cardiology®
Advanced searchSave search
Rapid Communication| Volume 91, ISSUE 11, P1392-1394, June 01, 2003

Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers

DOI:https://doi.org/10.1016/S0002-9149(03)00342-4
Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers
Previous ArticleFrequency of development of idiopathic dilated cardiomyopathy among relatives of patients with idiopathic dilated cardiomyopathy
Next ArticlePrenatal diagnosis and In Utero treatment of Torsades de Pointes associated with congenital long QT syndrome
      Pentaerythritol tetranitrate (PETN) is an organic nitrate that, like nitroglycerin (NTG), undergoes biotransformation to release its active metabolite nitric oxide or a nitric oxide adduct. Importantly, compared with other nitrates, PETN has been shown to have antioxidant properties and to inhibit the progression of atherosclerosis.
      • Hacker A.
      • Muller S.
      • Meyer W.
      • Kojda G.
      The nitric oxide donor pentaerythritol tetranitrate can preserve endothelial function in established atherosclerosis.
      Br J Pharmacol. 2001; 132: 1707-1714
      ,
      • Oberle S.
      • Schwartz P.
      • Abate A.
      • Schroder H.
      The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells.
      Biochem Biophys Res Commun. 1999; 261: 28-34
      Furthermore, animal studies and a recent report from our laboratory suggest that tolerance development does not occur during continuous therapy with PETN.
      • Mullenheim J.
      • Muller S.
      • Laber U.
      • Thamer V.
      • Meyer W.
      • Bassenge E.
      • Fink B.
      • Kojda G.
      The effect of high-dose pentaerythritol tetranitrate on the development of nitrate tolerance in rabbits (German).
      Naunyn Schmiedebergs Arch Pharmacol. 2001; 364: 269-275
      ,
      • Fink B.
      • Bassenge E.
      Unexpected, tolerance-devoid vasomotor and platelet actions of pentaerythrityl tetranitrate.
      J Cardiovasc Pharmacol. 1997; 30: 831-836
      ,
      • Dikalov S.
      • Fink B.
      • Skatchkov M.
      • Bassenge E.
      Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals effect of vitamin C.
      Free Radic Biol Med. 1999; 27: 170-176
      ,
      • Jurt U.
      • Gori T.
      • Ravandi A.
      • Babaei S.
      • Zeman P.
      • Parker J.D.
      Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation a human in vivo study.
      J Am Coll Cardiol. 2001; 38: 854-859
      These effects are consistent with the finding that PETN therapy is not associated with increased plasma concentrations of markers of oxidative stress.
      • Jurt U.
      • Gori T.
      • Ravandi A.
      • Babaei S.
      • Zeman P.
      • Parker J.D.
      Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation a human in vivo study.
      J Am Coll Cardiol. 2001; 38: 854-859
      In the present report, we investigated the effects of continuous therapy with transdermal NTG compared with oral PETN on endothelium-mediated vasodilation.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Hacker A.
        • Muller S.
        • Meyer W.
        • Kojda G.
        The nitric oxide donor pentaerythritol tetranitrate can preserve endothelial function in established atherosclerosis.
        Br J Pharmacol. 2001; 132: 1707-1714
        View in Article
        • Oberle S.
        • Schwartz P.
        • Abate A.
        • Schroder H.
        The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells.
        Biochem Biophys Res Commun. 1999; 261: 28-34
        View in Article
        • Mullenheim J.
        • Muller S.
        • Laber U.
        • Thamer V.
        • Meyer W.
        • Bassenge E.
        • Fink B.
        • Kojda G.
        The effect of high-dose pentaerythritol tetranitrate on the development of nitrate tolerance in rabbits (German).
        Naunyn Schmiedebergs Arch Pharmacol. 2001; 364: 269-275
        View in Article
        • Fink B.
        • Bassenge E.
        Unexpected, tolerance-devoid vasomotor and platelet actions of pentaerythrityl tetranitrate.
        J Cardiovasc Pharmacol. 1997; 30: 831-836
        View in Article
        • Dikalov S.
        • Fink B.
        • Skatchkov M.
        • Bassenge E.
        Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals.
        Free Radic Biol Med. 1999; 27: 170-176
        View in Article
        • Jurt U.
        • Gori T.
        • Ravandi A.
        • Babaei S.
        • Zeman P.
        • Parker J.D.
        Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation.
        J Am Coll Cardiol. 2001; 38: 854-859
        View in Article
        • Gori T.
        • Burstein J.M.
        • Ahmed S.
        • Miner S.E.
        • Al Hesayen A.
        • Kelly S.
        • Parker J.D.
        Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance.
        Circulation. 2001; 104: 1119-1123
        View in Article
        • Gori T.
        • Mak S.S.
        • Kelly S.
        • Parker J.D.
        Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans.
        J Am Coll Cardiol. 2001; 38: 1096-1101
        View in Article
        • Sutsch G.
        • Kim J.H.
        • Bracht C.
        • Kiowski W.
        Lack of cross-tolerance to short-term linsidomine in forearm resistance vessels and dorsal hand veins in subjects with nitroglycerin tolerance.
        Clin Pharmacol Ther. 1997; 62: 538-545
        View in Article
        • Petrie J.R.
        • Ueda S.
        • Morris A.D.
        • Murray L.S.
        • Elliott H.L.
        • Connell J.M.
        How reproducible is bilateral forearm plethysmography?.
        Br J Clin Pharmacol. 1998; 45: 131-139
        View in Article
        • Schulz E.
        • Tsilimingas N.
        • Rinze R.
        • Reiter B.
        • Wendt M.
        • Oelze M.
        • Woelken-Weckmuller S.
        • Walter U.
        • Reichenspurner H.
        • Meinertz T.
        • Munzel T.
        Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment.
        Circulation. 2002; 105: 1170-1175
        View in Article
        • Kojda G.
        • Hacker A.
        • Noack E.
        Effects of nonintermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production.
        Eur J Pharmacol. 1998; 355: 23-31
        View in Article
        • Kojda G.
        • Stein D.
        • Kottenberg E.
        • Schnaith E.M.
        • Noack E.
        In vivo effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate on the development of atherosclerosis and endothelial dysfunction in cholesterol-fed rabbits.
        J Cardiovasc Pharmacol. 1995; 25: 763-773
        View in Article
        • Oberle S.
        • Abate A.
        • Grosser N.
        • Vreman H.J.
        • Dennery P.A.
        • Schneider H.T.
        • Stalleicken D.
        • Schroder H.
        Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate.
        Biochem Biophys Res Commun. 2002; 290: 1539-1544
        View in Article

      Article info

      Publication history

      Accepted: February 20, 2003
      Received in revised form: February 20, 2003
      Received: October 14, 2002

      Footnotes

      This research was funded by a Grant-in-Aid B3160 from the Heart and Stroke Foundation of Ontario, Toronto, Ontario, Canada. Drs. Gori and Al-Hesayen are supported by a Research Fellowship, and Dr. Parker is the recipient of a Career Investigator Award from the Heart and Stroke Foundation of Ontario, Toronto, Ontario, Canada.

      Identification

      DOI: https://doi.org/10.1016/S0002-9149(03)00342-4

      Copyright

      © 2003 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX