Coronary vasospasm is characterized by transient myocardial ischemia resulting from
temporary coronary flow obstruction followed by reperfusion.
1
,
2
Several studies have suggested that left ventricular (LV) diastolic function may
be a more sensitive marker of coronary ischemia than systolic function.
3
,
4
,
5
,
6
It is conceivable that impaired or stunned regional diastolic function follows transient
severe myocardial ischemia associated with coronary vasospasm. To date, the postischemic
process of normalization of regional diastolic function in patients with coronary
vasospasm has not been investigated. We hypothesized that the adverse effect of spasm-induced
ischemia on regional diastolic function would persist well beyond the ischemic event.
Color kinesis (CK) (Philips Medical Systems, Andover, Massachusetts), a new technique
based on acoustic quantification, has recently been developed to facilitate the evaluation
of regional wall motion.
7
,
8
The present study was designed to investigate whether impaired regional LV wall motion
or diastolic asynchrony could actually be diagnosed using this method, and, if so,
how long the regional diastolic dysfunction persists after coronary vasospasm.To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Role of coronary artery spasm in symptomatic and silent myocardial ischemia.J Am Coll Cardiol. 1987; 9: 249-262
- Coronary arterial spasm in ischemic heart disease and its pathogenesis. A review.Circ Res. 1983; 52: 147-152
- Improved left ventricular diastolic filling in patients with coronary artery disease after percutaneous transluminal coronary angioplasty.Circulation. 1982; 66: 1159-1167
- Left ventricular systolic and diastolic function in coronary artery disease.Circulation. 1985; 72: 119-129
- Factors contributing to altered left ventricular diastolic properties during angina pectoris.Circulation. 1979; 59: 14-20
Sigwart U, Gribic M, Payot M, Goy J-J, Essinger A, Fischer A. Ischemic events during coronary balloon obstruction. In: Rutishauser W, Roskamm H, eds. Silent Myocardial Ischemia. Heidelberg, Germany: Springer-Verlag, 1984:29–36
- On-line assessment of ventricular function by automatic boundary detection and ultrasonic backscatter imaging.J Am Coll Cardiol. 1992; 19: 313-320
- Echocardiographic quantification of regional left ventricular wall motion with color kinesis.Circulation. 1996; 93: 1877-1885
- Comparative sensitivity of intracoronary injection of acetylcholine for the induction of coronary spasm in patients with various types of angina pectoris.Am Heart J. 1990; 120: 544-550
- Quantitative evaluation of global and regional left ventricular diastolic function with color kinesis.Circulation. 1998; 97: 1053-1061
- Segmental analysis of color kinesis images. New method for quantification of the magnitude and timing of endocardial motion during left ventricular systole and diastole.Circulation. 1997; 95: 2082-2097
- Effects of inotropic stimulation on segmental left ventricular relaxation quantified by color kinesis.Am J Cardiol. 2000; 85: 1476-1480
- Recommendations for the quantification of the left ventricle by two-dimensional echocardiography.J Am Soc Echocardiogr. 1989; 2: 358-367
- Diurnal distribution of ST-segment elevation and related arrhythmias in patients with variant angina.Circulation. 1983; 67: 995-1000
Article info
Publication history
Accepted:
February 24,
2003
Received in revised form:
February 24,
2003
Received:
November 5,
2002
Identification
Copyright
© 2003 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
