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Effect of systemic immunosuppression on coronary in-stent intimal hyperplasia in renal transplant patients

      Cyclosporin, combined with other agents, is an immunosuppressive agent approved for prophylaxis of renal transplant rejection. In experimental studies, cyclosporin has been shown to inhibit smooth muscle cell proliferation in the vascular response to injury.
      • Jonasson L.
      • Holm J.
      • Hansson G.K.
      Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury.
      ,
      • Voisard R.
      • Seitzer U.
      • Baur R.
      • Dartsch P.C.
      • Osterhues H.
      • Hoher M.
      • Hombach V.
      A prescreening system for potential antiproliferative agents implications for local treatment strategies of postangioplasty restenosis.
      Similar experimental results have been observed with systemic use of rapamycin.
      • Poon M.
      • Marx S.O.
      • Gallo R.
      • Badimon J.J.
      • Taubman M.B.
      • Marks A.R.
      Rapamycin inhibits vascular smooth muscle cell migration.
      ,
      • Burke S.E.
      • Lubbers N.L.
      • Chen Y.W.
      • Hsieh G.C.
      • Mollison K.W.
      • Luly J.R.
      • Wegner C.D.
      Neointimal formation after balloon-induced vascular injury in Yucatan minipigs is reduced by oral rapamycin.
      The aim of this clinical investigation was to test the hypothesis that systemic immunosuppression therapy inhibits in-stent restenosis in renal transplant patients with coronary artery disease treated with stenting.
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