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Relation of high lipoprotein(a) to other traditional atherosclerotic risk factors in patients with coronary heart disease

      Among emerging risk factors, high serum lipoprotein(a) (Lp(a)) may be an important marker for vascular disease or might be associated with other genetic or environmental factors that can cause atherosclerotic events.
      • Scheuner M.T.
      Genetic predisposition to coronary artery disease.
      A high serum Lp(a) level (>30 mg/dl) has been shown to be a significant risk factor for coronary heart disease (CHD) and myocardial infarction (MI) in several,
      • Rhoads G.G.
      • Dahlen G.
      • Berg K.
      • Morton N.E.
      • Dannenberg A.L.
      Lp(a) lipoprotein as a risk factor for myocardial infarction.
      ,
      • Bostom A.G.
      • Gagnon D.R.
      • Cupples L.A.
      • Wilson P.W.
      • Jenner J.L.
      • Ordovas J.M.
      • Schaefer E.J.
      • Castelli W.P.
      A prospective investigation of elevated lipoprotein (a) detected by electrophoresis and cardiovascular disease in women. The Framingham Heart Study.
      ,
      • Danesh J.
      • Collins R.
      • Peto R.
      Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies.
      but not all,
      • Ridker P.M.
      • Hennekens C.H.
      • Stampfer M.J.
      A prospective study of lipoprotein(a) and the risk of myocardial infarction.
      ,
      • Simons L.
      • Friedlander Y.
      • Simons J.
      • McCallum J.
      Lipoprotein(a) is not associated with coronary heart disease in the elderly cross-sectional data from the Dubbo study.
      previous studies. The present study examines the relation of serum Lp(a) to: (1) age at onset of CHD; (2) severity of CHD at first presentation; (3) traditional risk factor burden; and (4) presence of family history of premature CHD (men <55 years old , women <65 years old) in a cohort of patients with established CHD being followed in a secondary prevention clinic.
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