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Effect of atorvastatin (80 mg) on recurrent ischemia in unstable angina pectoris or Non–ST-Elevation acute myocardial infarction

      Agrowing body of evidence has suggested that many cellular actions of statin therapy may acutely improve endothelial function even before affecting the lipid profile.
      • Sposito A.C.
      • Chapman M.J.
      Statin therapy in acute coronary syndromes mechanistic insight into clinical benefit.
      Statins can acutely enhance nitric oxide bioavailability via their lipid-independent actions by upregulating endothelial nitric oxide synthase.
      • Tsunekawa T.
      • Hayashi T.
      • Kano H.
      • Sumi D.
      • Matsui-Hirai H.
      • Thakur N.K.
      • Egashira K.
      • Iguchi A.
      Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days.
      In this randomized clinical trial, we evaluated the effect of high-dose atorvastatin on myocardial ischemia measured by ST-segment monitoring during the first 2 days after an episode of unstable angina pectoris (UAP) or non–Q-wave acute myocardial infarction (AMI).
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