Agrowing body of evidence has suggested that many cellular actions of statin therapy
may acutely improve endothelial function even before affecting the lipid profile.
1
Statins can acutely enhance nitric oxide bioavailability via their lipid-independent
actions by upregulating endothelial nitric oxide synthase.
2
In this randomized clinical trial, we evaluated the effect of high-dose atorvastatin
on myocardial ischemia measured by ST-segment monitoring during the first 2 days after
an episode of unstable angina pectoris (UAP) or non–Q-wave acute myocardial infarction
(AMI).To read this article in full you will need to make a payment
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References
- Statin therapy in acute coronary syndromes.Arterioscler Thromb Vasc Biol. 2002; 22: 1524-1534
- Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days.Circulation. 2001; 104: 376-379
- Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris.Circulation. 1996; 94: 1503-1505
Flegg H. An investigation of the determination of serum cholesterol by an enzymatic method. Ann Clin Biochem 1973:79–84
- Prevalence and significance of transient—predominantly asymptomatic—myocardial ischemia on Holter monitoring in unstable angina pectoris, and correlation with exercise test and thallium-201 myocardial perfusion imaging.Am J Cardiol. 1993; 72: 144-148
- Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes.JAMA. 2001; 285: 1711-1718
- Effects of atorvastatin 80 mg daily early after onset of unstable angina pectoris or non–Q-wave myocardial infarction.Am J Cardiol. 2002; 90: 872-874
- Effect of fluvastatin on ischaemia following acute myocardial infarction.Eur Heart J. 2002; 23: 1931-1937
Article info
Publication history
Accepted:
February 24,
2003
Received in revised form:
February 24,
2003
Received:
November 22,
2002
Identification
Copyright
© 2003 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.