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Comparison of effects of abciximab versus eptifibatide on C-reactive protein, interleukin-6, and interleukin-1 receptor antagonist after coronary arterial stenting

      Multiple markers of inflammation have been shown to increase after coronary stenting.
      • Gaspardone A.
      • Crea F.
      • Versaci F.
      • Tomai F.
      • Pellegrino A.
      • Chiariello L.
      • Gioffre P.A.
      Predictive value of C-reactive protein after successful coronary artery stenting in patients with stable angina.
      ,
      • Versaci F.
      • Gaspardone A.
      • Tomai F.
      • Crea F.
      • Chiariello L.
      • Gioffre P.A.
      Predictive value of C-reactive protein in patients with unstable angina pectoris undergoing coronary artery stent implantation.
      ,
      • Liuzzo G.
      • Buffon A.
      • Biasucci L.M.
      • Gallimore J.R.
      • Caligiuri G.
      • Vitelli A.
      • Altamura S.
      • Ciliberto G.
      • Rebuzzi A.G.
      • Crea F.
      • Pepys M.B.
      • Maseri A.
      Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina.
      C-reactive protein (CRP), a prototypic acute phase reactant, is induced by interleukin (IL)-6.
      • Ganter U.
      • Arcone R.
      • Toniatti C.
      • Morrone G.
      • Ciliberto G.
      Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6.
      IL-1 induces inflammation and augments production of IL-6.
      • Ng S.B.
      • Tan Y.H.
      • Guy G.R.
      Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1.
      Concentrations of IL-1 receptor antagonist increase concomitantly with those of IL-1 and are easier to measure than IL-1.
      • Fischer E.
      • van Zee K.J.
      • Marano M.A.
      • Rock C.S.
      • Kenney J.S.
      • Poutsiaka D.D.
      • Dinarello C.A.
      • Lowry S.F.
      • Moldawer L.L.
      Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease.
      A correlation between increases in the concentrations of these markers after coronary stenting and adverse events has been demonstrated.
      • Gaspardone A.
      • Crea F.
      • Versaci F.
      • Tomai F.
      • Pellegrino A.
      • Chiariello L.
      • Gioffre P.A.
      Predictive value of C-reactive protein after successful coronary artery stenting in patients with stable angina.
      ,
      • Versaci F.
      • Gaspardone A.
      • Tomai F.
      • Crea F.
      • Chiariello L.
      • Gioffre P.A.
      Predictive value of C-reactive protein in patients with unstable angina pectoris undergoing coronary artery stent implantation.
      The present study is a prospective, randomized comparison of the effects of abciximab and eptifibatide on changes in the concentrations in blood of high-sensitivity CRP, IL-6, and IL-1 receptor antagonist during the first 24 hours after coronary stent implantation.
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