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One-year results of percutaneous myocardial revascularization for refractory angina pectoris

      Several registry studies have reported clinical improvement after percutaneous myocardial revascularization (PMR).
      • Shawl F.A.
      • Domanski M.J.
      • Kaul U.
      • Dougherty K.G.
      • Hoff S.
      • Rigali G.E.
      • Cornell S.L.
      • Shahab S.T.
      Procedural results and early clinical outcome of percutaneous transluminal myocardial revascularization.
      ,
      • Kornowski R.
      • Baim D.S.
      • Moses J.W.
      • Hong M.K.
      • Laham R.J.
      • Fuchs S.
      • Hendel R.C.
      • Wallace D.
      • Cohen D.J.
      • Bonow R.O.
      • Kuntz R.E.
      • Leon M.B.
      Short- and intermediate-term clinical outcomes from direct myocardial laser revascularization guided by Biosense left ventricular electromechanical mapping.
      ,
      • Lauer B.
      • Junghans U.
      • Stahl F.
      • Kluge R.
      • Oesterle S.N.
      • Schuler G.
      Catheter-based percutaneous myocardial laser revascularization in patients with end-stage coronary artery disease.
      ,
      • Laham R.J.
      • Simons M.
      • Pearlman J.D.
      • Ho K.K.
      • Baim D.S.
      Magnetic resonance imaging demonstrates improved regional systolic wall motion and thickening and myocardial perfusion of myocardial territories treated by laser myocardial revascularizaton.
      ,
      • Wiemer M.
      • Butz T.
      • Wielepp J.P.
      • Fassbender D.
      • Burchert W.
      Improvement of myocardial perfusion detected by positron emission tomography in patients with end-stage coronary artery disease treated with percutaneous myocardial laser revascularisation (abstr).
      The Potential Angina Class Improvement From Intramyocardial Channels (PACIFIC) trial reported results from the first randomized trial of PMR versus medical therapy, and improvement in angina pectoris, treadmill time, and quality of life (QOL) 1 year after PMR was found.
      • Oesterle S.N.
      • Sanborn T.A.
      • Ali N.
      • Resar J.
      • Ramee S.R.
      • Heuser R.
      • Dean L.
      • Knopf W.
      • Schofield P.
      • Schaer G.L.
      • et al.
      Percutaneous Transmyocardial Laser Revascularisation for Severe Angina the PACIFIC randomised trial.
      After encouraging results with a different holmium yttrium-aluminum-garnet (holmium-YAG) laser and fiber optic system in a registry series,
      • Whitlow P.L.
      • Knopf W.D.
      • O’Neill W.W.
      • Kaul U.
      • Londero H.
      • Shawl F.A.
      Percutaneous transmyocardial revascularization in patients with refractory angina (abstr).
      a randomized trial of PMR with a 1-mm, triple pulsed optical fiber versus maximal medical therapy was begun. This investigation reports the results of this prospective, randomized multicenter trial using the Eclipse system (Eclipse Surgical Technologies, Sunnyvale, California).
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