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Relation of hypertriglyceridemia to plasma concentrations of biochemical markers of inflammation and endothelial activation (C-reactive protein, interleukin-6, soluble adhesion molecules, von Willebrand factor, and endothelin-1)

      We have previously shown that flow-mediated endothelium-dependent vasodilation, measured by ultrasound of the brachial artery, is impaired in healthy young men after experimental triglyceridemia
      • Lundman P.
      • Eriksson M.
      • Schenck-Gustafsson K.
      • Karpe F.
      • Tornvall P.
      Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease.
      and in young men with persistent mild to moderate hypertriglyceridemia.
      • Lundman P.
      • Eriksson M.
      • Stuehlinger M.
      • Cooke J.
      • Hamsten A.
      • Tornvall P.
      Mild to moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine.
      Similarly, other investigators
      • de Man F.H.
      • Weverling-Rijnsburger A.W.
      • van der Laarse A.
      • Smelt A.H.
      • Jukema J.W.
      • Blauw G.J.
      Not acute but chronic hypertriglyceridemia is associated with impaired endothelium-dependent vasodilation reversal after lipid-lowering therapy by atorvastatin.
      ,
      • Lewis T.V.
      • Dart A.M.
      • Chin-Dusting J.P.
      Endothelium-dependent relaxation by acetylcholine is impaired in hypertriglyceridemic humans with normal levels of plasma LDL cholesterol.
      showed that hypertriglyceridemia is associated with impaired pharmacologically stimulated endothelium-dependent vasodilation measured by plethysmography. These investigations indicate that hypertriglyceridemia is associated with functional impairment of the endothelium, whereas there is a paucity of studies investigating biochemical markers of endothelial activation in hypertriglyceridemia. One study showed increased plasma concentrations of soluble cell adhesion molecules together with decreased flow-mediated vasodilation.
      • Lupattelli G.
      • Lombardini R.
      • Schillaci G.
      • Ciuffetti G.
      • Marchesi S.
      • Siepi D.
      • Mannarino E.
      Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia association with small, dense LDL cholesterol particles.
      Another study demonstrated that patients with severe hypertriglyceridemia have increased plasma levels of cell adhesion molecules, which were decreased by triglyceride-lowering treatment.
      • Abe Y.
      • El-Masri B.
      • Kimball K.T.
      • Pownall H.
      • Reilly C.F.
      • Osmundsen K.
      • Smith C.W.
      • Ballantyne C.M.
      Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on monocyte adhesion.
      The present report examines whether persistent mild to moderate hypertriglyceridemia in healthy young men is associated with elevated plasma concentrations of biochemical markers of inflammation and endothelial activation.
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