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Relation between plaque composition and vascular remodeling in coronary lesions with different degrees of lumen narrowing as assessed with three-dimensional intravascular ultrasound in patients with stable angina pectoris

      There is an ongoing debate about whether hard plaques (in particular calcified lesions) are associated with constrictive or expansive remodeling. Previous intravascular ultrasound (IVUS) studies of stenoses with significant lumen narrowing that were targets for percutaneous coronary interventions
      • Mintz G.S.
      • Kent K.M.
      • Pichard A.D.
      • Satler L.F.
      • Popma J.J.
      • Leon M.B.
      Contribution of inadequate arterial remodeling to the development of focal coronary artery stenoses an intravascular ultrasound study.
      ,
      • Tauth J.
      • Pinnow E.
      • Sullebarger J.T.
      • Basta L.
      • Gursoy S.
      • Lindsay Jr, J.
      • Matar F.
      Predictors of coronary arterial remodeling patterns in patients with myocardial ischemia.
      ,
      • Weissman N.J.
      • Sheris S.J.
      • Chari R.
      • Mendelsohn F.O.
      • Anderson W.D.
      • Breall J.A.
      • Tanguay J.F.
      • Diver D.J.
      Intravascular ultrasonic analysis of plaque characteristics associated with coronary artery remodeling.
      ,
      • Fuessl R.T.
      • Kranenberg E.
      • Kiausch U.
      • Baer F.M.
      • Sechtem U.
      • Hopp H.W.
      Vascular remodeling in atherosclerotic coronary arteries is affected by plaque composition.
      ,
      • Beckman J.A.
      • Ganz J.
      • Creager M.A.
      • Ganz P.
      • Kinlay S.
      Relationship of clinical presentation and calcification of culprit coronary artery stenosis.
      have shown that hard plaques are typically associated with constrictive remodeling. In contrast, a recent histologic study in atherosclerotic coronary vessels with varying degrees of lumen narrowing suggested otherwise.
      • Burke A.P.
      • Kolodgie F.D.
      • Farb A.
      • Weber D.
      • Virmani R.
      Morphological predictors of arterial remodeling in coronary atherosclerosis.
      For that reason, we used 3-dimensional IVUS
      • von Birgelen C.
      • de Vrey E.A.
      • Mintz G.S.
      • Nicosia A.
      • Bruining N.
      • Li W.
      • Slager C.J.
      • Roelandt J.R.T.C.
      • Serruys P.W.
      • de Feyter P.J.
      ECG-gated three-dimensional intravascular ultrasound feasibility and reproducibility of the automated analysis of coronary lumen and atherosclerotic plaque dimensions in humans.
      ,
      • von Birgelen C.
      • van der Lugt A.
      • Nicosia A.
      • Mintz G.S.
      • Gussenhoven E.J.
      • de Vrey E.
      • Mallus M.T.
      • Roelandt J.R.T.C.
      • Serruys P.W.
      • de Feyter P.J.
      Computerized assessment of coronary lumen and atherosclerotic plaque dimensions in three-dimensional intravascular ultrasound correlated with histomorphometry.
      to carefully examine 130 focal coronary plaques with a wide range of lumen narrowings to compare plaque composition and vascular remodeling in vivo.
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