Abstract
In experimental studies, the importance of aldosterone for the development of left
ventricular (LV) hypertrophy has been demonstrated. In 120 healthy Caucasian men (aged
25 ± 3 years; blood pressure, 134 ± 15/86 ± 12 mm Hg), we determined LV mass (2-dimensionally
guided M-mode echocardiography), urinary aldosterone concentration, and the response
of aldosterone to angiotensin II infusion (3.0 ng/kg/min). Seventy-six volunteers
took part in a follow-up visit after 2 years when urinary aldosterone concentration
and LV mass were determined again. At follow-up, LV mass increased in 42 subjects
(by 33 ± 26 g), whereas in 34 subjects LV mass decreased (by 27 ± 22 g). Between the
2 groups, only the change in urinary aldosterone concentration over time was significantly
different (group with increased LV mass had an increase in urinary aldosterone concentration
by 2.5 ± 5.4 μg/day; group with decreased LV mass had a decrease in urinary aldosterone
concentration by 0.7 ± 4.6; p <0.01 between groups). In accordance, we found significant
correlations between changes in LV mass and changes in urinary aldosterone concentration
(r = 0.29, p <0.05) and between changes in LV mass and the response of aldosterone
to angiotensin II at baseline (r = 0.25, p <0.05). Both changes in aldosterone concentration
over time and the response of aldosterone to angiotensin II were related to changes
in LV mass over time. These data underscore the importance of aldosterone for the
development of LV hypertrophy. This process is already evident in young subjects with
apparently small changes in LV mass over a mean follow-up period of 2 years.
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Article info
Publication history
Accepted:
September 16,
2002
Received in revised form:
September 16,
2002
Received:
July 8,
2002
Footnotes
☆This study was supported by grant DFG KFG 106-1 from the Deutsche Forschungsgemeinschaft, Bonn, Germany, to Dr. Schmieder.
Identification
Copyright
© 2003 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
