Regular paper| Volume 91, ISSUE 3, P297-301, February 01, 2003

Functional Relevance of Aldosterone for the Determination of Left Ventricular Mass


      In experimental studies, the importance of aldosterone for the development of left ventricular (LV) hypertrophy has been demonstrated. In 120 healthy Caucasian men (aged 25 ± 3 years; blood pressure, 134 ± 15/86 ± 12 mm Hg), we determined LV mass (2-dimensionally guided M-mode echocardiography), urinary aldosterone concentration, and the response of aldosterone to angiotensin II infusion (3.0 ng/kg/min). Seventy-six volunteers took part in a follow-up visit after 2 years when urinary aldosterone concentration and LV mass were determined again. At follow-up, LV mass increased in 42 subjects (by 33 ± 26 g), whereas in 34 subjects LV mass decreased (by 27 ± 22 g). Between the 2 groups, only the change in urinary aldosterone concentration over time was significantly different (group with increased LV mass had an increase in urinary aldosterone concentration by 2.5 ± 5.4 μg/day; group with decreased LV mass had a decrease in urinary aldosterone concentration by 0.7 ± 4.6; p <0.01 between groups). In accordance, we found significant correlations between changes in LV mass and changes in urinary aldosterone concentration (r = 0.29, p <0.05) and between changes in LV mass and the response of aldosterone to angiotensin II at baseline (r = 0.25, p <0.05). Both changes in aldosterone concentration over time and the response of aldosterone to angiotensin II were related to changes in LV mass over time. These data underscore the importance of aldosterone for the development of LV hypertrophy. This process is already evident in young subjects with apparently small changes in LV mass over a mean follow-up period of 2 years.
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        • Levy D.
        • Garrisin R.J.
        • Savage D.D.
        • Kannel W.B.
        • Castelli W.P.
        Prognostic implications of echocardiographically determined left ventricular mass in The Framingham Study.
        N Engl J Med. 1990; 322: 1561-1566
        • Schillaci G.
        • Verdecchia P.
        • Porcellati C.
        • Cuccurullo O.
        • Cosco C.
        • Perticone F.
        Continuous relation between left ventricular mass and cardiovascular risk in essential hypertension.
        Hypertension. 2000; 35: 580-586
        • Duprez D.A.
        • Bauwens F.R.
        • De Buyzere M.L.
        • De Backer T.L.
        • Kaufman J.M.
        • Van Hoecke J.
        • Vermuelen A.
        • Clement D.L.
        Influence of arterial blood pressure and aldosterone on left ventricular hypertrophy in moderate essential hypertension.
        Am J Cardiol. 1993; 71: 17A-20A
        • Schlaich M.P.
        • Schobel H.P.
        • Hilgers K.
        • Schmieder R.E.
        Impact of aldosterone on left ventricular structure and function in young normotensive and mildly hypertensive subjects.
        Am J Cardiol. 2000; 85: 1199-1206
        • Delles C.
        • Erdmann J.
        • Jacobi J.
        • Fleck E.
        • Regitz-Zagrosek V.
        • Schmieder R.E.
        Lack of association between polymorphisms of angiotensin II receptor genes and response to short-term angiotensin II infusion.
        J Hypertens. 2000; 18: 1573-1578
        • Luft F.C.
        • Fineberg N.S.
        • Sloan R.S.
        Estimating dietary sodium intake in individuals receiving a randomly fluctuating intake.
        Hypertension. 1982; 4: 805-808
        • Devereux R.B.
        • Lutas E.M.
        • Casale P.N.
        • Kligfield P.
        • Eisenberg R.R.
        • Hammond I.W.
        • Miller D.H.
        • Reis G.
        • Alderman M.H.
        • Laragh J.H.
        Standardization of M-mode echocardiographic left ventricular anatomic measurements.
        J Am Coll Cardiol. 1984; 4: 1222-1230
        • Devereux R.B.
        • Alonso D.R.
        • Lutas E.M.
        • Gottlieb G.J.
        • Campo E.
        • Sachs I.
        • Reichek N.
        Echocardiographic assessment of left ventricular hypertrophy.
        Am J Cardiol. 1986; 56: 450-458
        • Jacobi J.
        • Schlaich M.P.
        • Delles C.
        • Schobel H.P.
        • Schmieder R.E.
        Angiotensin II stimulates left ventricular hypertrophy in hypertensive patients independently of blood pressure.
        Am J Hypertens. 1999; 12: 418-422
        • Schlaich M.P.
        • Klingbeil A.U.
        • Jacobi J.
        • Delles C.
        • Schneider M.P.
        • Schmidt B.M.
        • Schmieder R.E.
        Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension.
        J Hypertens. 2002; 20: 117-124
        • Delles C.
        • Erdmann J.
        • Jacobi J.
        • Hilgers K.F.
        • Fleck E.
        • Regitz-Zagrosek V.
        • Schmieder R.E.
        Aldosterone synthase (CYP11B2)-344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension.
        J Am Coll Cardiol. 2001; 37: 878-884
        • Kupari M.
        • Hautanen A.
        • Lankinen L.
        • Koskinen P.
        • Virolainen J.
        • Nikkila H.
        • White P.C.
        Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function.
        Circulation. 1998; 97: 569-575
        • Messerli F.H.
        • Sundgaard-Riise K.
        • Ventura H.O.
        • Dunn F.G.
        • Oigman W.
        • Frohlich E.D.
        Clinical and hemodynamic determinants of left ventricular dimensions.
        Arch Intern Med. 1984; 144: 477-481
        • Hubel W.
        • Thomas L.
        in: Thomas L. Labor und Diagnose. TH Books Verlagsgesellschaft mbH, Frankfurt a Main1998: 1046-1061
        • De Simone G.
        • Ganau A.
        • Verdecchia P.
        • Devereux R.B.
        Echocardiography in arterial hypertension.
        J Hypertens. 1994; 12: 1129-1136