Advertisement

Angiographic findings in monozygotic twins with coronary artery disease

      Both genetic and environmental factors are involved in the development of coronary artery disease (CAD).
      • Marenberg M.E.
      • Risch N.
      • Berkman L.F.
      • Floderus B.
      • de Faire U.
      Genetic susceptibility to death from coronary heart disease in a study of twins.
      ,
      • Frings A.M.
      • Mayer B.
      • Bocker W.
      • Hengstenberg C.
      • Willemsen D.
      • Riegger G.A.
      • Schunkert H.
      Comparative coronary anatomy in six twin pairs with coronary artery disease.
      The degree of contribution of each individual risk factor on CAD is unknown. The influence of genetics in the development of CAD could be clarified by investigation of twins. A large cohort of twins with CAD had a significantly higher concordance of coronary heart death in monozygotic twins than dizygotic twins.
      • Marenberg M.E.
      • Risch N.
      • Berkman L.F.
      • Floderus B.
      • de Faire U.
      Genetic susceptibility to death from coronary heart disease in a study of twins.
      This effect declined with age.
      • Marenberg M.E.
      • Risch N.
      • Berkman L.F.
      • Floderus B.
      • de Faire U.
      Genetic susceptibility to death from coronary heart disease in a study of twins.
      These observations underscore the genetic influence in the development of CAD. Little is known about the angiographic expression of CAD in twins. To address this issue, we report findings of 2 monozygotic twin pairs with CAD and a systematic review of previous publications on this topic.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Cardiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Marenberg M.E.
        • Risch N.
        • Berkman L.F.
        • Floderus B.
        • de Faire U.
        Genetic susceptibility to death from coronary heart disease in a study of twins.
        N Engl J Med. 1994; 330: 1041-1046
        • Frings A.M.
        • Mayer B.
        • Bocker W.
        • Hengstenberg C.
        • Willemsen D.
        • Riegger G.A.
        • Schunkert H.
        Comparative coronary anatomy in six twin pairs with coronary artery disease.
        Heart. 2000; 83: 47-50
        • Kaluza G.
        • Abukhalil J.M.
        • Raizner A.E.
        Identical atherosclerotic lesions in identical twins.
        Circulation. 2000; 101: E63-E64
        • Samuels L.E.
        • Samuels F.S.
        • Thomas M.P.
        • Morris R.J.
        • Wechsler A.S.
        Coronary artery disease in identical twins.
        Ann Thorac Surg. 1999; 68: 594-600
        • Schilling R.J.
        • Norell M.S.
        Coronary artery disease in identical twins.
        Eur Heart J. 1995; 16: 134-135
        • Russo P.
        • Steffenino G.
        • Dellavalle A.
        • Ribichini F.
        Concomitant myocardial infarction in identical twins with similar coronary lesions.
        G Ital Cardiol. 1995; 25: 341-343
        • Kanda T.
        • Ohshima S.
        • Yuasa K.
        • Toyama T.
        • Takase S.
        Painless myocardial infarction in identical diabetic twins.
        Jpn J Med. 1991; 30: 170-174
        • Herrington D.M.
        • Pearson T.A.
        Clinical and angiographic similarities in twins with coronary artery disease.
        Am J Cardiol. 1987; 59: 366-367
        • Holmes D.R.J.
        • Kennel A.J.
        • Smith H.C.
        • Gordon H.
        • Moore S.B.
        Coronary artery disease in twins.
        Br Heart J. 1981; 45: 193-197
        • Boschat J.
        • Ollivier J.P.
        • Blanc J.J.
        • Penther P.
        Coronary disease in homozygous twins. Respective roles of heredity and environment.
        Arch Mal Coeur Vaiss. 1981; 74: 237-240
        • Kreulen T.H.
        • Cohn P.F.
        • Gorlin R.
        Premature coronary artery disease in identical male twins studied by selective coronary arteriography.
        Cathet Cardiovasc Diagn. 1975; 1: 91-96
        • Sidd J.J.
        • Sasahara A.A.
        • Littmann D.
        Coronary-artery disease in identical twins. A family study.
        N Engl J Med. 1966; 274: 55-60
        • Giknis F.L.
        • Holt D.E.
        • Whiteman H.W.
        • Singh M.D.
        • Benchimol A.
        • Dimond E.G.
        Myocardial infarction in twenty year old identical twins.
        Am J Cardiol. 1965; 16: 122-126
        • Baim D.
        • Grossmann W.
        Cardiac Catheterization, Angiography, and Intervention.
        in: 5th ed. Williams & Wilkens, Baltimore1996: 199-200
        • Subcommittee on Percutaneous Transluminal coronary Angioplasty
        A report of the American College of Cardiology/American Heart Association Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures.
        J Am Coll Cardiol. 1988; 12: 529-545