Abstract
Arterial distensibility decreases with age and atherosclerosis leading to increased
pulse pressure (PP) and increased left ventricular work, resulting in left ventricular
hypertrophy, a risk factor for cardiovascular morbidity. Brachial artery pulse curve
data were collected using the DynaPulse 2000A. Distensibility measured in 920 healthy
young adults (40% men, 70% white, age range 18 to 38 years) was compared with levels
of cardiovascular risk factors. Laboratory, anthropometric, blood pressure (BP), and
heart rate measurements were also obtained. Distensibility tended to decrease with
age, reaching significance in women (p <0.05). Whites had greater distensibility adjusted
for age than blacks, with women more than men (p <0.05). Distensibility adjusted for
PP was negatively correlated with measures of body size, BP, glucose, insulin, low-density
lipoprotein cholesterol , very low densitiy lipoprotein cholesterol, and age (p <0.05).
When distensibility was plotted as a function of PP to control for distending pressure,
the lowest quintiles of systolic, diastolic, and mean arterial BPs tended to have
greater distensibility. No differences were seen by quintiles of lipids. In multivariate
analyses, BP, age, anthropometric measures, gender, and very low density lipoprotein
cholesterol entered the model (r2 = 0.56; p <0.02). Thus, brachial artery distensibility, which includes a normalization
factor to control for body size, showed race and gender differences (whites and women
had greater distensibility than blacks and men, respectively), even after adjustment
for age. Stiffer vessels with decreased distensibility were seen in subjects with
higher levels of cardiovascular risk factors across the range of normal PP. Therefore,
noninvasive measures of distensibility are useful in measuring subclinical vascular
changes related to arteriosclerosis.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study).Am J Cardiol. 1992; 70: 851-858
- Decreased arterial elasticity associated with cardiovascular disease risk factors in the young. The Bogalusa Heart Study.Arteriosclerosis. 1992; 6: 378-386
- Correlation of ultrasound-measured common carotid artery stiffness with pathological findings.Arterioscler Thromb. 1992; 14: 479-482
- Noninvasive pulse wave analysis for the early detection of vascular disease.Hypertension. 1992; 26: 503-508
- Arterial compliance by cuff sphygmomanometer; Application to hypertension and early changes in subjects at genetic risk.Hypertension. 1992; 28: 599-603
- Studies of blood pressures in children, ages 5-14 years, in a total biracial community:.Circulation. 1992; 54: 319-327
- Development, and validation of a non-invasive method to determine arterial pressure, and vascular compliance.Am J Cardiol. 1992; 80: 323-330
- Validation of pulse dynamic blood pressure measurement by auscultation.Blood Press Monit. 1992; 3: 121-124
- Epidemiology of early cardiovascular disease:.Am J Human Biol. 1992; 5: 433-450
- Race and gender differences in serum lipoproteins of children, adolescents, and young adults:.Prev Med. 1992; 20: 671-684
- Corresponding pulse pressure and arterial compliance variations during ambulatory monitoring.in: Portaluppi F. Smolensky M.H. Time-Dependent Structure and Control of Arterial Blood Pressure. Ann NY Acad Sci, New York1996: 310-312
- Reduced vascular compliance as a marker for essential hypertension.Am J Hypertens. 1992; 4: 245-251
- Age associated alterations in structure and function of the cardiovascular system.Am J Geriatr Cardiol. 1992; 7: 15-22
- Aging, changes in the cardiovascular system, and responses to stress.Am J Hypertens. 1992; 11: 41S-45S
- Arterial wall hypertrophy and stiffness in essential hypertensive patients.Hypertension. 1992; 26: 355-362
- Forearm arterial distensibility in systolic hypertension.J Am Coll Cardiol. 1992; 3: 387-393
- Age-related abnormalities in arterial compliance identified by pressure pulse contour analysis:.Hypertension. 1992; 33: 1392-1398
- Age-related differences in elastic properties of the upper arm vascular bed in healthy adults.J Vasc Res. 1992; 34: 137-147
- Age-related changes in total arterial capacitance from birth to maturity in a normotensive population.Hypertension. 1992; 29: 1213-1217
- Effect of age on brachial artery wall properties differs from the aorta and is gender dependent: a:.Hypertension. 1992; 35: 637-642
- Arterial stiffness.J Hypertens. 1992; 17: 1-4
- Sex steroids, insulin, and arterial stiffness in women and men.Hypertension. 1992; 34: 590-597
- Arterial compliance and distensibility are modulated by body composition in both men and women but by insulin sensitivity only in women.Diabetologia. 1992; 42: 214-221
- Vascular abnormalities in non-insulin-dependent diabetes mellitus identified by arterial waveform analysis.Am J Med. 1992; 95: 424-430
- Abnormalities of vascular compliance in hypertension, aging and heart failure.J Hypertens. 1992; 10: S61-S64
- Noninvasive determination of age-related changes in the human arterial pulse.Circulation. 1992; 80: 1652-1659
- Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study.Circulation. 1992; 91: 1432-1443
- Contributions of vascular tone and structure to elastic properties of a medium-sized artery.Hypertension. 1992; 27: 816-822
- Large-artery elastic properties in young men:.Arterioscler Thromb Vasc Biol. 1992; 19: 436-441
Article Info
Publication History
Accepted:
December 28,
2001
Received in revised form:
December 28,
2001
Received:
August 29,
2001
Footnotes
☆This study was supported by Grant 5R01 HL38844 from the National Heart, Lung, and Blood Institute of the U.S. Public Health Service “Early Natural History of Arteriosclerosis,” Bethesda, Maryland.
Identification
Copyright
© 2002 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
