This study sought to determine the relation between fasting glucose levels, coronary
heart disease (CHD) risk factors, and the prevalence of CHD in a high-risk group of
patients attending a cardiology prevention clinic. The study was designed to address
2 questions. (1) Are increasing fasting glucose concentrations in the nondiabetic
range (≤125 mg/dl) associated with an increased burden of traditional (smoking, central
obesity, systemic hypertension, dyslipidemia) and nontraditional (e.g., fibrinogen,
homocysteine, lipoprotein(a) [Lp(a)]) CHD risk factors? (2) Are increasing blood glucose
concentrations in this range associated with a continuous and graded risk for CHD
independent of these risk factors?
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of CardiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Report of the Expert Committee on the diagnosis and classification of diabetes mellitus.Diabetes Care. 2000; 23: S4-S19
- The sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNCVI).Arch Intern Med. 1997; 157: 2413-2446
- Manual of Laboratory Operations, Lipid and Lipoprotein Analysis.in: Hainline A Karon J Lippel K HEW Publication no. (NIH) 75–628 (revised). National Heart, Lung and Blood Institute (US Government Printing Office No. 1982–361–132, Bethesda, MD1982: 678
- Rapid HPLC determination of total homocysteine and other thiols in serum and plasma.Clin Chem. 1994; 40: 873-881
- The relative power of heat-precipitation nephelometric and clottable (Clauss) fibrinogen in the prediction ofischaemic heart disease.Br J Haematol. 1998; 100: 582-588
- Assessing the fit of the model.in: In: Applied Logistic Regression. John Wiley & Sons, New York1989: 140-145
- Metabolic risk factors worsen continuously across the spectrum of nondiabetic glucose tolerance. The Framingham Offspring Study.Ann Intern Med. 1998; 128: 524-533
- Fasting blood glucose.Diabetes Care. 1999; 22: 45-49
- Is there a glycemic threshold for mortality risk?.Diabetes Care. 1999; 22: 696-699
- Is glucose a continuous risk factor for cardiovascular mortality?.Diabetes Care. 1999; 22 ([editorial]): 659-660
- Relationship of glucose and insulin levels to the risk of myocardial infarction.J Am Coll Cardiol. 1999; 33: 612-619
- Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study).Am J Cardiol. 2000; 86: 309-312
- Glucose tolerance and cardiovascular mortality.Arch Intern Med. 2001; 161: 397-405
- The relationship between glucose and incident cardiovascular events.Diabetes Care. 1999; 22: 233-240
Article Info
Publication History
Accepted:
November 14,
2001
Received in revised form:
November 14,
2001
Received:
August 8,
2001
Identification
Copyright
© 2002 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
