Discussion| Volume 89, ISSUE 5, P571-585, March 01, 2002

Joseph Kayle Perloff, MD: a conversation with the editor*

        Joseph Perloff was born in New Orleans, Louisiana, on December 21, 1924. After public grade school and private high school in New Orleans, he entered Tulane University, from which he graduated in 1945 with a BA in English Literature. Following his military service as an ensign in the United States Navy in the Pacific Theater and in China, Dr. Perloff returned to the USA, decided to go to medical school, and obtained his premedical credentials at the University of Chicago. In 1947, he entered Louisiana State University School of Medicine in New Orleans, graduating in 1951. He then served as an intern at Mt. Sinai Hospital in New York, followed by residencies in pathology and medicine at the same institution. Dr. Perloff was awarded a Fulbright Fellowship to the Institute of Cardiology, National Heart Hospital in London, where he worked with Dr. Paul Hamilton Wood. Dr. Perloff was exposed to a broad age range of cardiac patients at the National Heart Hospital, because British cardiology was not then subspecialized according to age. After a year in London, Dr. Perloff moved to Washington, DC, and to Georgetown University Medical Center to complete his residency in medicine, followed by an NIH sponsored fellowship in Cardiology. He remained on the faculty at Georgetown, rising to full professor in 1970. Two years later, he moved to Philadelphia as Chief of the Cardiovascular Section at the University of Pennsylvania School of Medicine until 1977, when he moved to Los Angeles as Professor of Medicine and Pediatrics at the University of California, Los Angeles School of Medicine. In 1980, he founded what was destined to become the Ahmanson/UCLA Adult Congenital Heart Disease Center, of which he was Director until 2001. In 1983, he was named to the newly endowed Streisand/American Heart Association Chair as Professor of Medicine and Pediatrics (Figure 1).
        Figure thumbnail GR1
        FIGURE 1JKP in the UCLA Hospital Echocardiography Laboratory.
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        Further reading

        JKP’s best publications as selected by JKPbooks

        1. Perloff JK. The Heart in Neuromuscular Disease. Chicago, IL: Year Book Medical Publishers, Inc, 1986.

        2. Perloff JK, Child JS. Congenital Heart Disease in Adults. 2nd Edition. Philadelphia, PA: WB Saunders Co, 1998.

        3. Perloff JK. Physical Examination of the Heart and Circulation. 3rd Edition. Philadelphia, PA: WB Saunders Co, 2000.

        4. Perloff JK. The Clinical Recognition of Congenital Heart Disease. 5th Edition. Philadelphia: WB Saunders Co, in press.


        1. Perloff JK, Harvey WP. The clinical recognition of tricuspid stenosis. Circulation 1960;22:346.

        2. Perloff JK. The recognition of strictly posterior myocardial infarction by conventional scalar electrocardiography. Circulation 1964;30:706.

        3. Perloff JK, deLeon AC, O’Doherty D. The cardiomyopathy of progressive muscular dystrophy. Circulation 1966;33:625.

        4. Perloff JK, Roberts WC, deLeon AC, O’Doherty D. The distinctive electrocardiogram of Duchenne’s progressive muscular dystrophy: an electrocardiographic-pathologic correlative study. Am J Med 1967;42:179.

        5. Perloff JK, Roberts WC. The mitral apparatus: functional anatomy of mitral regurgitation. Circulation 1972;46:227.

        6. Perloff JK. Pediatric congenital cardiac becomes a post-operative adult: the changing population of congenital heart disease. Circulation 1973;47:606.

        7. Perloff JK. The physiologic mechanisms of cardiac and vascular physical signs. J Am Coll Cardiol 1983;1:184.

        8. Perloff JK, Henze E, Schelbert HR. Alterations in regional myocardial metabolism, perfusion and wall motion in Duchenne muscular dystrophy studied by radionuclide imaging. Circulation 1984;69:33.

        9. Ross EA, Perloff JK, Danovitch GM, Child JS, Canobbio MM. Renal function and urate metabolism in late survivors with cyanotic congenital heart disease. Circulation 1986;73:396.

        10. Child JS, Perloff JK, Bach PM, Wolfe AD, Perlman S, Kark RAP. Cardiac involvement in Friedreich’s ataxia: a clinical study of 75 patients. J Am Coll Cardiol 1986;7:1370.

        11. Sietsema KE, Cooper DR, Rosove MH, Perloff JK, Child JS, Canobbio MM, Whipp BJ, Wasserman K. Dynamics of oxygen uptake during exercise in adults with cyanotic congenital heart disease. Circulation 1986;73:1137.

        12. Rosove MH, Perloff JK, Hocking WG, Child JS, Canobbio MM, Skorton DJ. Chronic hypoxaemia and decompensated erythrocytosis in cyanotic congenital heart disease. Lancet 1986;II:313.

        13. Sietsema KE, Cooper DM, Perloff JK, Child JS, Rosove MH, Wasserman K, Whipp BJ. Control of ventilation during exercise in patients with central venous to systemic arterial shunts. J Appl Physiol 1988;64:234.

        14. Stevenson WC, Perloff JK, Weiss JN, Anderson TL. Facioscapulohumeral muscular dystrophy; evidence for selective, genetic electrophysiologic cardiac involvement. J Am Coll Cardiol 1990;15:292.

        15. Chin TK, Perloff JK, Williams RG, Jue K, Morhmann R. Isolated non-compaction of left ventricular myocardium. Circulation 1990;82:507.

        16. Perloff JK (editor). Proceedings of the 22nd Bethesda Conference. Congenital Heart disease after pediatrics: an expanding population. J Am Coll Cardiol 1991;18:311.

        17. Perloff JK, Moise NS, Gilmour RF, Stevenson WG. Cardiac electrophysiology of Duchenne muscular dystrophy: from basic science to clinical expression. J Cardiovasc Electrophysiol 1992;3:394.

        18. Perloff JK, Marelli AJ, Miner PD. Risk of stroke in adults with cyanotic congenital heart disease. Circulation 1993;87:1954.

        19. Territo MC, Perloff JK, Rosove MH, Moake JL, Runge A. Acquired von Willebrand factor abnormality in adults with congenital heart disease. Clin Appl Thrombosis/Hemostasis 1998;4:257.

        20. Niwa K, Perloff JK, Kaplan S, Child JS, Miner PD. Eisenmenger syndrome in adults, ventricular septal defect, truncus arteriosus, univentricular heart. J Am Coll Cardiol 1999;34:223.

        21. Perloff JK, Latta H. Pathogenesis of the glomerular abnormality in cyanotic congenital heart disease. Am J Cardiol 2000;86:1198.

        22. Perloff JK, Niwa K, Bhuta S, Laks H, Drinkwater D, Child JS, Miner P. Structural abnormalities of great arterial walls in congenital heart disease. Light and electron microscopic analyses. Circulation 2001;103:393.