In contrast to nonspecific elevations of myoglobin and creatine kinase-MB (CK-MB)
in athletes due to exertional rhabdomyolysis of trained skeletal muscle,
1
,
2
reported increases in cardiospecific troponins after competition may indicate silent
injury to the myocardium.
3
,
4
,
5
,
6
,
7
,
8
We therefore undertook serial testing of multiple cardiac markers used to diagnose
early- and late-stage myocardial injury in the same group of middle-aged runners before
and sequentially after 5 Boston marathons over 4 years. In addition to CK-MB and myoglobin,
cardiac troponin I (cTnI) was tested by a qualitative rapid assay in 1997, a high-sensitivity
reference method in 1998 to 2000, and a rapid quantitative method to detect acute
myocardial infarction (AMI) in 2001 together with cTnT. Selective postrace single-photon
emission computed tomography (SPECT) with technetium-99m sestamibi myocardial scintigraphy
and B-natriuretic peptide (BNP) levels were used to assess microinfarction and transient
left ventricular dysfunction, respectively.To read this article in full you will need to make a payment
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References
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Article Info
Publication History
Accepted:
May 25,
2001
Received in revised form:
May 25,
2001
Received:
December 29,
2000
Identification
Copyright
© 2001 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
