Abstract
A growing body of evidence indicates that measurements of postprandial glucose levels,
in combination with glycosylated hemoglobin, are a more accurate predictor of metabolic
abnormality than fasting or preprandial glucose levels for individuals with type 2
diabetes. Early identification of elevated postprandial blood glucose levels is an
important step in predicting the onset of microvascular and macrovascular complications
that can progress to full symptomatic diabetes. This article summarizes the research
conducted to date on the diagnostic import of postprandial glucose and the parameters
established for judging the need for treatment. When individuals cannot reach target
glucose levels through diet and exercise, medical treatment is necessary. The article
reviews a range of treatment options, including insulin secretagogues, insulin sensitizers,
antiabsorptive agents, weight reduction agents, and insulin and combination medical
therapy.
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© 2001 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
