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Insulin resistance but not β-cell dysfunction is predictive of increased atherosclerosis in asymptomatic individuals without diabetes
      The insulin resistance syndrome consists of a peripheral resistance to the action of insulin combined with several metabolic abnormalities. It is associated with an increased risk of symptomatic coronary artery disease (CAD), even in the absence of clinical diabetes mellitus. Electron-beam computed tomography (EBCT) coronary artery scanning identifies asymptomatic individuals with increased coronary plaque mass, as well as increased likelihood of obstructive coronary disease and future cardiovascular events. EBCT may be used to ascertain coronary disease risk in persons with varying degrees of the insulin resistance syndrome.
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