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Interaction of the paraoxonase genes pon1 and pon2 and the methylenetetrahydrofolate reductase gene and association with coronary artery calcification using electron-beam computed tomography
      Serum paraoxonase (PON) is a high-density lipoprotein-associated enzyme with antiatherosclerotic properties including inhibition of low-density lipoprotein oxidation. Recently, it has been implicated in the breakdown of proatherogenic homocysteine metabolites. PON may therefore provide protection against the risk of coronary artery disease (CAD). Polymorphisms in the PON1 (Gln192Arg) and PON2 (Ser311Cys) genes have been associated with risk for CAD.
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