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Effect of red wine and ethanol on production of nitric oxide in healthy subjects

      Direct analysis of nitric oxide (NO) has been a difficult task owing to its instability and low concentration in tissues.
      • Moncada S.
      • Palmer R.M.J.
      • Higgs E.A.
      Nitric oxide physiology, pathophysiology and pharmacology.
      However, a new selective fluorescent indicator, diaminofluoresceins (DAF-2), enabled the direct detection of NO under physiologic conditions.
      • Kojima H.
      • Nakatsubo N.
      • Kikuchi K.
      • Kawahara S.
      • Kirino Y.
      • Nagoshi H.
      • Hirata Y.
      • Nagano T.
      Detection and imaging of nitric oxide with novel fluorescent indicators.
      ,
      • Takahashi M.
      • Matsumoto T.
      • Yokohama H.
      • Omura T.
      • Horie H.
      Detection of physiological nitric oxide by a new fluorescent indicator 4,5-diaminofluorescein (DAF-2) (abstr).
      This study was performed to clarify the acute effect of red wine, ethanol, and polyphenol on the production of NO and oxidative stress in healthy subjects.
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