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Left ventricular function in Nigerian Africans with non–insulin-dependent diabetes mellitus

      Clinical and epidemiologic studies have suggested that patients with diabetes mellitus could develop myocardial dysfunction in the absence of epicardial coronary artery disease, systemic hypertension, or valvular heart disease.
      • Fein F.S.
      • Sonneblick E.M.
      Diabetic cardiomyopathy.
      ,
      • Regan T.J.
      Congestive heart failure in the diabetic.
      In 1972, Rubler et al
      • Rubler S.
      • Dlugash J.
      • Yueoglu Y.Z.
      • Kumral T.
      • Branwood A.W.
      • Grishmar A.
      New type of cardiomyopathy associated wityh diabetic glomerulosclerosis.
      reported 4 patients with adult-onset diabetes who had cardiomegaly and congestive heart failure in the absence of coronary artery disease or hypertension. The assessment of left ventricular (LV) function as an index of potential myocardial involvement in the diabetic patient without clinical evidence of myocardial ischemia or other cardiovascular abnormalities has become increasingly important. This is particularly true in settings like ours where diabetics with no other comorbidity factor for heart disease rarely present with heart failure. The use of echocardiography in assessing LV dimensions and function has offered a direct method for obtaining quantitative assessment of myocardial function. This study evaluates LV function in patients with non–insulin-dependent diabetes mellitus in our environment using echocardiography with a view to determining any cardiac morbidity.
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      References

        • Fein F.S.
        • Sonneblick E.M.
        Diabetic cardiomyopathy.
        Prog Cardiovasc Dis. 1985; 27: 255-270
        • Regan T.J.
        Congestive heart failure in the diabetic.
        Ann Rev Med. 1983; 34: 161-168
        • Rubler S.
        • Dlugash J.
        • Yueoglu Y.Z.
        • Kumral T.
        • Branwood A.W.
        • Grishmar A.
        New type of cardiomyopathy associated wityh diabetic glomerulosclerosis.
        Am J Cardiol. 1972; 30: 595-602
        • Sahn D.J.
        • De Maria A.
        • Kisslo Y.
        • Weyman A.
        Recommendations regarding quantitation in M-mode echocardiography results of a survey of echocardiographic measurements.
        Circulation. 1978; 58: 1071-1081
        • Feigenbaum H.
        Echocardiographic evaluation of cardiac chambers.
        in: Feigenbaum H. Echocardiography. 3rd ed. Lea & Febiger, Philadelphia1981: 119-187
        • Devereux R.B.
        • Reichek N.
        Echocardiographic determination of left ventricular mass in men.
        Circulation. 1977; 55: 613-618
        • Zarich S.W.
        • Nesto R.W.
        Diabetic cardiomyopathy.
        Am Heart J. 1989; 118: 1000-1012
        • Fraser G.E.
        • Luke R.
        • Thompson S.
        • Smith H.
        • Centers Sharpe N.
        Comparison of echocardiography variables between type I diabetes and normal controls.
        Am J Cardiol. 1995; 75: 141-145
        • Galderisi M.
        • Anderson K.M.
        • Wilson P.W.F.
        • Levy D.
        Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (The Framingham Heart Study).
        Am J Cardiol. 1991; 68: 85-89
        • Porcellati C.
        • Gatteschi C.
        • Benemio G.
        • Guerrieri M.
        • Boldrini F.
        • Verdecchia P.
        Echocardiographic analysis of the left ventricle in patients with type II diabetes mellitus.
        J Ital Cardiol. 1989; 19: 128-135
        • Rubler S.
        • Sajadi M.R.M.
        • Araoye M.A.
        • Holford F.D.
        Non-invasive estimation of myocardial performance in patients with diabetes. Effects of alcohol administration.
        Diabetes. 1979; 27: 127-138
        • Shapiro L.M.
        Echocardiographic features of impaired ventricular function in diabetes mellitus.
        Br Heart J. 1982; 47: 439-444
        • Takenaka K.
        • Sakamoto K.
        Left ventricular filling determined by Doppler echocardiography in diabetes mellitus.
        Am J Cardiol. 1988; 61: 1140-1143
        • Sanderson J.E.
        • Brown D.J.
        • Rivellese A.
        • Kohner E.
        Diabetic cardiomyopathy? An echocardiographic study of young diabetics.
        Br Med J. 1978; 1: 404-407
        • Regan T.J.
        • Lyons M.M.
        • Ahmed S.S.
        • Levinson G.E.
        • Oldewurtel H.A.
        • Ahmed M.R.
        • Haider B.
        Evidence for cardiomyopathy in familial diabetes mellitus.
        J Clin Invest. 1977; 60: 885-899
        • Attali J.R.
        • Sachs R.N.
        • Valensi P.
        Asymptomatic diabetic cardiomyopathy.
        Diabetes Res Clin Pract. 1988; 4: 183-190
        • Uusitupa M.
        • Mustonen J.
        • Laakso M.
        • Lansimies E.
        • Talwar S.
        • Pyoralo K.
        • Vianio P.
        Impairment of diastolic function in middle aged type I and type diabetic patients free of cardiovascular disease.
        Diabetologia. 1988; 31: 783-791