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Rapid Communication| Volume 87, ISSUE 8, P1011-1013, April 15, 2001

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Coronary vasoconstriction after coronary angioplasty is attenuated by endothelin a receptor antagonism

DOI:https://doi.org/10.1016/S0002-9149(01)01441-2
Coronary vasoconstriction after coronary angioplasty is attenuated by endothelin a receptor antagonism
Previous ArticleA simple, readily available method for risk stratification of patients with unstable angina and non-ST elevation myocardial infarction
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      Previous studies have demonstrated distal coronary vasoconstriction immediately after percutaneous transluminal coronary angioplasty (PTCA). It was presumed that this coronary vasoconstriction is the result of intimal injury or endothelial dysfunction,
      • Suter T.M.
      • Buechi M.
      • Hess O.M.
      • Haemmerli-Saner C.
      • Gaglione A.
      • Krayenbuehl H.P.
      Normalization of coronary vasomotion after percutaneous transluminal coronary angioplasty?.
      Circulation. 1992; 85: 86-92
      abnormal autoregulatory tone,
      • Fischell T.A.
      • Derby G.
      • Tse T.M.
      • Stadius M.L.
      Coronary artery vasoconstriction routinely occurs after percutaneous transluminal coronary angioplasty a quantitative arteriographic analysis.
      Circulation. 1988; 78: 1323-1334
      ,
      • Fischell T.A.
      • Bausback K.N.
      • McDonald T.V.
      Evidence of altered epicardial coronary artery autoregulation as a cause of distal coronary vasoconstriction after successful coronary artery angioplasty.
      J Clin Invest. 1990; 86: 575-584
      ,
      • El-Tamimi H.
      • Davies G.J.
      • Hackett D.
      • Sritara P.
      • Bertrand O.
      • Crea F.
      • Maseri A.
      Abnormal vasomotor changes early after coronary angioplasty a quantitative angiographic study of their time course.
      Circulation. 1991; 84: 1198-1202
      formation of vasoactive substances,
      • Golino P.
      • Piscione F.
      • Benedict C.R.
      • Anderson H.V.
      • Cappelli-Bigazzi M.
      • Indolfi C.
      • Condorelli M.
      • Chiariello M.
      • Willerson J.T.
      Local effect of serotonin released during coronary angioplasty.
      N Engl J Med. 1994; 330: 523-528
      ,
      • McFadden E.P.
      • Clarke J.G.
      • Davies G.
      • Kaski J.C.
      • Haider A.W.
      • Maseri A.
      Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina.
      N Engl J Med. 1991; 324: 648-654
      impaired release of endothelial-derived relaxing factor,
      • Harrison D.G.
      • Bates J.N.
      The nitrovasodilator new ideas about old drugs.
      Circulation. 1993; 87: 1461-1467
      and activation of adrenergic neural reflexes.
      • Gregorini L.
      • Fajadet J.
      • Robert G.
      • Cassagneau B.
      • Bernis M.
      • Marco J.
      Coronary vasoconstriction after percutaneous transluminal coronary angioplasty is attenuated by antiadrenergic agents.
      Circulation. 1994; 90: 895-907
      Endothelin-1 (ET-1) levels have been found to be elevated after PTCA.
      • Kyriakides Z.S.
      • Markianos M.
      • Iliodromitis E.K.
      • Kremastinos D.T.
      Vein plasma endothelin-1 and cyclic GMP increase during angioplasty is related to myocardial ischemia.
      Eur Heart J. 1995; 16: 894-898
      ET-1 produces very potent and marked vasoconstriction in vitro as well as in vivo.
      • Levin E.R.
      Endothelins.
      N Engl J Med. 1995; 336: 356-363
      ET-1 binds to at least 2 receptors: in blood vessels, endothelin A (ETA) receptors are present only on vascular smooth muscle cells and cause contraction, whereas endothelin B receptors are on endothelium, causing vasodilatation, and on vascular smooth muscle cells, causing contraction. In healthy men, the major receptor causing vasoconstriction, at least in the systemic circulation, is the ETA receptor.
      • Haynes W.G.
      • Webb D.J.
      The endothelin family of peptides local hormones with diverse roles in health and disease?.
      Clin Sci. 1993; 84: 485-500
      ,
      • Verhaar M.C.
      • Strachan F.E.
      • Newby D.E.
      • Cruden N.L.
      • Koomans H.A.
      • Rabelink T.J.
      • Webb D.J.
      Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.
      Circulation. 1998; 97: 752-756
      ,
      • Strachan F.E.
      • Spratt J.C.
      • Wilkinson I.B.
      • Gray G.A.
      • Johnston N.R.
      • Webb D.J.
      Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men.
      Hypertension. 1999; 33: 581-585
      Endogenously produced ET-1 contributes to the maintenance of basal coronary artery tone in humans with and without coronary artery disease.
      • Kyriakides Z.S.
      • Kremastinos Dth
      • Bofilis E.
      • Tousoulis D.
      • Antoniadis A.
      • Webb D.J.
      Endogenous endothelin type A receptor stimulation in patients undergoing coronary arteriography.
      Heart. 2000; 84: 176-182
      The aim of this study was to test the hypothesis that ETA receptor stimulation contributes to the coronary artery vasoconstriction observed after PTCA.
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      References

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        • Buechi M.
        • Hess O.M.
        • Haemmerli-Saner C.
        • Gaglione A.
        • Krayenbuehl H.P.
        Normalization of coronary vasomotion after percutaneous transluminal coronary angioplasty?.
        Circulation. 1992; 85: 86-92
        View in Article
        • Fischell T.A.
        • Derby G.
        • Tse T.M.
        • Stadius M.L.
        Coronary artery vasoconstriction routinely occurs after percutaneous transluminal coronary angioplasty.
        Circulation. 1988; 78: 1323-1334
        View in Article
        • Fischell T.A.
        • Bausback K.N.
        • McDonald T.V.
        Evidence of altered epicardial coronary artery autoregulation as a cause of distal coronary vasoconstriction after successful coronary artery angioplasty.
        J Clin Invest. 1990; 86: 575-584
        View in Article
        • El-Tamimi H.
        • Davies G.J.
        • Hackett D.
        • Sritara P.
        • Bertrand O.
        • Crea F.
        • Maseri A.
        Abnormal vasomotor changes early after coronary angioplasty.
        Circulation. 1991; 84: 1198-1202
        View in Article
        • Golino P.
        • Piscione F.
        • Benedict C.R.
        • Anderson H.V.
        • Cappelli-Bigazzi M.
        • Indolfi C.
        • Condorelli M.
        • Chiariello M.
        • Willerson J.T.
        Local effect of serotonin released during coronary angioplasty.
        N Engl J Med. 1994; 330: 523-528
        View in Article
        • McFadden E.P.
        • Clarke J.G.
        • Davies G.
        • Kaski J.C.
        • Haider A.W.
        • Maseri A.
        Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina.
        N Engl J Med. 1991; 324: 648-654
        View in Article
        • Harrison D.G.
        • Bates J.N.
        The nitrovasodilator.
        Circulation. 1993; 87: 1461-1467
        View in Article
        • Gregorini L.
        • Fajadet J.
        • Robert G.
        • Cassagneau B.
        • Bernis M.
        • Marco J.
        Coronary vasoconstriction after percutaneous transluminal coronary angioplasty is attenuated by antiadrenergic agents.
        Circulation. 1994; 90: 895-907
        View in Article
        • Kyriakides Z.S.
        • Markianos M.
        • Iliodromitis E.K.
        • Kremastinos D.T.
        Vein plasma endothelin-1 and cyclic GMP increase during angioplasty is related to myocardial ischemia.
        Eur Heart J. 1995; 16: 894-898
        View in Article
        • Levin E.R.
        Endothelins.
        N Engl J Med. 1995; 336: 356-363
        View in Article
        • Haynes W.G.
        • Webb D.J.
        The endothelin family of peptides.
        Clin Sci. 1993; 84: 485-500
        View in Article
        • Verhaar M.C.
        • Strachan F.E.
        • Newby D.E.
        • Cruden N.L.
        • Koomans H.A.
        • Rabelink T.J.
        • Webb D.J.
        Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.
        Circulation. 1998; 97: 752-756
        View in Article
        • Strachan F.E.
        • Spratt J.C.
        • Wilkinson I.B.
        • Gray G.A.
        • Johnston N.R.
        • Webb D.J.
        Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men.
        Hypertension. 1999; 33: 581-585
        View in Article
        • Kyriakides Z.S.
        • Kremastinos Dth
        • Bofilis E.
        • Tousoulis D.
        • Antoniadis A.
        • Webb D.J.
        Endogenous endothelin type A receptor stimulation in patients undergoing coronary arteriography.
        Heart. 2000; 84: 176-182
        View in Article
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      Article info

      Publication history

      Accepted: November 6, 2000
      Received in revised form: November 6, 2000
      Received: September 7, 2000

      Identification

      DOI: https://doi.org/10.1016/S0002-9149(01)01441-2

      Copyright

      © 2001 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.

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