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Association between plasma folate and coronary disease independent of homocysteine

      Numerous studies have reported an association between increased homocysteine, low plasma folate, and coronary disease. These studies are generally interpreted as meaning that low folate status affects cardiovascular risk by increasing homocysteine levels, perhaps involving a common mutation in the gene for methylenetetrahydrofolate reductase (MTHFR). We examined the relation between coronary disease and homocysteine and plasma and red cell folate in 255 hospitalized coronary patients <65 years old and 114 age-matched population controls. Details of the study population and laboratory methods have been described previously.
      • Silberberg J
      • Crooks R
      • Fryer J
      • Wlodarczyk J
      • Nair B
      • Guo X.W
      • Xie L.J
      Gender differences and other determinants of the rise in plasma homocysteine after L-methionine loading.
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      References

        • Silberberg J
        • Crooks R
        • Fryer J
        • Wlodarczyk J
        • Nair B
        • Guo X.W
        • Xie L.J
        Gender differences and other determinants of the rise in plasma homocysteine after L-methionine loading.
        Atherosclerosis. 1997; 133: 105-110
        • Molloy A.M
        • Mills J.L
        • Kirke P.N
        • Whitehead A.S
        • Weir D.G
        • Scott J.M
        Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes.
        Clin Chem. 1998; 44: 186-188
        • Verhoef P
        • Kok F.J
        • Kruyssen D.A.C.M
        • Schouten E.G
        • Witteman J.C.M
        • Grobbee D.E
        • Ueland P.M
        • Refsum H
        Plasma total homocysteine, B vitamins and risk of coronary atherosclerosis.
        Arterioscl Thromb Vasc Biol. 1997; 17: 989-995
        • Herbert V
        Making sense of laboratory tests of folate status.
        Am J Hematol. 1987; 26: 199-207
        • Usui M
        • Matsouka H
        • Miyazaki H
        • Ueda S
        • Okuda S
        • Imaizumi T
        Endothelial dysfunction by acute hyperhomocyst(e)inaemia.
        Clin Sci. 1999; 96: 235-239
        • Verhaar M.C
        • Wever R.M.F
        • Kastelein J.J.P
        • van Loon D
        • Milstien S
        • Koomans H.A
        • Rabelink T.J
        Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial.
        Circulation. 1999; 100: 335-338
        • Stroes E.S.G
        • van Faassen E.E
        • Yo M
        • Martasek P
        • Boer P
        • Govers R
        • Rabelink T.J
        Folic acid reverts dysfunction of endothelial nitric oxide synthase.
        Circ Res. 2000; 86: 1129-1134